Matthew S Sigman
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Explore the profile of Matthew S Sigman including associated specialties, affiliations and a list of published articles.
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242
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4722
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Recent Articles
1.
Bartholomew G, Karas L, Eason R, Yeung C, Sigman M, Sarpong R
J Med Chem
. 2025 Mar;
PMID: 40053676
Heteroaromatics are the basis for many pharmaceuticals. The ability to modify these structures through selective core-atom transformations, or "skeletal edits", can dramatically expand the landscape for drug discovery and development....
2.
Zwick 3rd C, Eckhoff M, Henle J, Bay A, Swiatowiec R, Shekhar S, et al.
J Am Chem Soc
. 2025 Feb;
PMID: 39947636
Sulfur-derived functional groups represent prevalent motifs in highly sought-after small molecules, such as active pharmaceutical ingredients (APIs). Thioethers are one such example, being commonly encountered in APIs, prodrugs, and as...
3.
Call A, Palone A, Liles J, Romer N, Read J, Luis J, et al.
ACS Catal
. 2025 Feb;
15(3):2110-2123.
PMID: 39944762
Enantioselective C(sp)-H bond oxidation is a powerful strategy for installing functionality in C(sp)-H rich molecules. Site- and enantioselective oxidation of strong C-H bonds in monosubstituted cyclohexanes with hydrogen peroxide catalyzed...
4.
Duker J, Philipp M, Lentner T, Cadge J, Lavarda J, Gschwind R, et al.
ACS Catal
. 2025 Jan;
15(2):817-827.
PMID: 39839851
Transition metal catalysis is crucial for the synthesis of complex molecules, with ligands and bases playing a pivotal role in optimizing cross-coupling reactions. Despite advancements in ligand design and base...
5.
Hernandez-Mejias A, Shimozono A, Hazra A, Richter S, Tong Z, Langille N, et al.
J Am Chem Soc
. 2025 Jan;
147(4):3468-3477.
PMID: 39807561
Ni-catalyzed asymmetric reductive cross-coupling reactions provide rapid and modular access to enantioenriched building blocks from simple electrophile precursors. Reductive coupling reactions that can diverge through a common organometallic intermediate to...
6.
Interrogation of Enantioselectivity in the Photomediated Ring Contractions of Saturated Heterocycles
Kim S, Liles J, Lux M, Park H, Jurczyk J, Soda Y, et al.
J Am Chem Soc
. 2025 Jan;
147(2):1851-1866.
PMID: 39746148
We recently reported a chiral phosphoric acid (CPA) catalyzed enantioselective photomediated ring contraction of piperidines and other saturated heterocycles. By extruding a single heteroatom from a ring, this transformation builds...
7.
Haas B, Kalyani D, Sigman M
Sci Adv
. 2025 Jan;
11(1):eadt3013.
PMID: 39742471
The application of statistical modeling in organic chemistry is emerging as a standard practice for probing structure-activity relationships and as a predictive tool for many optimization objectives. This review is...
8.
Haas B, Hardy M, Sowndarya S V S, Adams K, Coley C, Paton R, et al.
Digit Discov
. 2024 Dec;
4(1):222-233.
PMID: 39664609
Data-driven reaction discovery and development is a growing field that relies on the use of molecular descriptors to capture key information about substrates, ligands, and targets. Broad adaptation of this...
9.
Read J, Ball T, Miller B, Jacobsen E, Sigman M
J Org Chem
. 2024 Nov;
89(23):17237-17247.
PMID: 39580661
A quantitative and predictive understanding of how attractive noncovalent interactions (NCIs) influence functional outcomes is a long-standing goal in mechanistic chemistry. In that context, better comprehension of how substituent effects...
10.
Boni Y, Cammarota R, Liao K, Sigman M, Davies H
J Am Chem Soc
. 2024 Sep;
146(40):27972.
PMID: 39342635
No abstract available.