Matthew R Stump
Overview
Explore the profile of Matthew R Stump including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
125
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0
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Recent Articles
1.
Stump M, Nguyen R, Drgastin R, Search D, Gong Q, Zhou Z
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33467093
The Kv11.1 voltage-gated potassium channel, encoded by the KCNH2 gene, conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative polyadenylation to generate two C-terminal Kv11.1...
2.
Gong Q, Stump M, Zhou Z
J Biol Chem
. 2018 Nov;
293(51):19624-19632.
PMID: 30377250
The () gene encodes the Kv11.1 potassium channel, which conducts the rapidly activating delayed rectifier current in the heart. pre-mRNA undergoes alternative polyadenylation and forms a functional, full-length Kv11.1a isoform...
3.
Gong Q, Stump M, Zhou Z
Gene
. 2017 Oct;
641:220-225.
PMID: 29066300
The KCNH2 or human ether-a go-go-related gene (hERG) encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier potassium current in the heart. The expression of Kv11.1 C-terminal...
4.
Gong Q, Stump M, Zhou Z
J Mol Cell Cardiol
. 2014 Aug;
76:26-32.
PMID: 25128783
The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative processing; intron 9 splicing leads to the...
5.
Gong Q, Stump M, Deng V, Zhang L, Zhou Z
Circ Cardiovasc Genet
. 2014 Jul;
7(4):482-90.
PMID: 25028483
Background: The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. The relative expression of the full-length Kv11.1a isoform and the...
6.
Gong Q, Stump M, Zhou Z
Gene
. 2014 Feb;
539(2):190-7.
PMID: 24530480
The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC) mutations by nonsense-mediated mRNA decay (NMD) is an important mechanism of long QT syndrome type 2...
7.
Stump M, Gong Q, Zhou Z
Am J Physiol Heart Circ Physiol
. 2013 Sep;
305(9):H1397-404.
PMID: 23997099
The human ether-a-go-go-related gene (hERG) encodes a voltage-activated K(+) channel that contributes to the repolarization of the cardiac action potential. Long QT syndrome type 2 (LQT2) is an autosomal dominant...
8.
Stump M, Gong Q, Packer J, Zhou Z
J Mol Cell Cardiol
. 2012 Sep;
53(5):725-33.
PMID: 22964610
Mutations in the human ether-a-go-go-related gene (hERG) result in long QT syndrome type 2 (LQT2). The hERG gene encodes a K(+) channel that contributes to the repolarization of the cardiac...
9.
Stump M, Gong Q, Zhou Z
PLoS One
. 2012 Aug;
7(8):e42552.
PMID: 22876326
Background: Mutations in the human ether-a-go-go-related gene 1 (hERG1) cause type 2 long QT syndrome (LQT2). The hERG1 gene encodes a K(+) channel with properties similar to the rapidly activating...
10.
Zarraga I, Zhang L, Stump M, Gong Q, Michael Vincent G, Zhou Z
Heart Rhythm
. 2011 Mar;
8(8):1200-6.
PMID: 21419236
Background: Nonsense and frameshift mutations are common in congenital long QT syndrome type 2 (LQT2). We previously demonstrated that hERG nonsense mutations cause degradation of mutant mRNA by nonsense-mediated mRNA...