Matthew Pelc
Overview
Explore the profile of Matthew Pelc including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
2
Citations
106
Followers
0
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Recent Articles
1.
Gierse J, Thorarensen A, Beltey K, Bradshaw-Pierce E, Cortes-Burgos L, Hall T, et al.
J Pharmacol Exp Ther
. 2010 Apr;
334(1):310-7.
PMID: 20392816
Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC), and it is up-regulated in many inflammatory conditions, including but not limited to cancer,...
2.
Meyers M, Pelc M, Kamtekar S, Day J, Poda G, Hall M, et al.
Bioorg Med Chem Lett
. 2010 Feb;
20(5):1543-7.
PMID: 20137931
The work described herein demonstrates the utility of structure-based drug design (SBDD) in shifting the binding mode of an HTS hit from a DFG-in to a DFG-out binding mode resulting...