Matthew J Thomas
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Explore the profile of Matthew J Thomas including associated specialties, affiliations and a list of published articles.
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65
Citations
2029
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Recent Articles
11.
Weckerle J, Picart-Armada S, Klee S, Bretschneider T, Luippold A, Rist W, et al.
Dis Model Mech
. 2021 Nov;
15(1).
PMID: 34845494
Alterations in metabolic pathways were recently recognized as potential underlying drivers of idiopathic pulmonary fibrosis (IPF), translating into novel therapeutic targets. However, knowledge of metabolic and lipid regulation in fibrotic...
12.
Sunmonu N, Ambati N, Thomas M, Ulep R, Worrall B
J Stroke Cerebrovasc Dis
. 2021 Oct;
30(12):106123.
PMID: 34666234
Objective: To investigate potential genetic susceptibility for moyamoya disease (MMD) in an African American family. Materials And Methods: Neurovascular imaging and analyses of MMD susceptibility genes RNF213 and/or ACTA2 in...
13.
Thomas M, Cassidy E, Robinson D, Walstrom K
Biochim Biophys Acta Proteins Proteom
. 2021 Oct;
1870(1):140722.
PMID: 34619358
Malate dehydrogenase (MDH) catalyzes the conversion of NAD and malate to NADH and oxaloacetate in the citric acid cycle. Eukaryotes have one MDH isozyme that is imported into the mitochondria...
14.
Ison H, Griffin E, Parrott A, Shikany A, Meyers L, Thomas M, et al.
J Genet Couns
. 2021 Sep;
31(1):9-33.
PMID: 34510635
Congenital heart disease (CHD) is an indication which spans multiple specialties across various genetic counseling practices. This practice resource aims to provide guidance on key considerations when approaching counseling for...
15.
Le H, Hill M, Kollak I, Keck M, Schroeder V, Wirth J, et al.
EMBO Rep
. 2021 Jul;
22(8):e52785.
PMID: 34224201
Unveiling the molecular mechanisms of tissue remodelling following injury is imperative to elucidate its regenerative capacity and aberrant repair in disease. Using different omics approaches, we identified enhancer of zester...
16.
Perry M, Bjorhall K, Bold P, Brulls M, Borjesson U, Carlsson J, et al.
J Med Chem
. 2021 Jun;
64(12):8053-8075.
PMID: 34080862
Starting from our previously described PI3Kγ inhibitors, we describe the exploration of structure-activity relationships that led to the discovery of highly potent dual PI3Kγδ inhibitors. We explored changes in two...
17.
Wood R, Pratt A, Kenward C, McWilliams C, Booton R, Thomas M, et al.
Med Decis Making
. 2021 Feb;
41(4):393-407.
PMID: 33560181
Background: During the COVID-19 pandemic, many intensive care units have been overwhelmed by unprecedented levels of demand. Notwithstanding ethical considerations, the prioritization of patients with better prognoses may support a...
18.
Vasse G, Nizamoglu M, Heijink I, Schleputz M, van Rijn P, Thomas M, et al.
J Pathol
. 2021 Jan;
254(4):344-357.
PMID: 33506963
Fibrosis results from aberrant wound healing and is characterized by an accumulation of extracellular matrix, impairing the function of an affected organ. Increased deposition of extracellular matrix proteins, disruption of...
19.
Zuo W, Rostami M, LeBlanc M, Kaner R, OBeirne S, Mezey J, et al.
PLoS One
. 2020 Sep;
15(9):e0237529.
PMID: 32941426
Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic fibrotic lung disease with an irreversible decline of lung function. "Bronchiolization", characterized by ectopic appearance of airway epithelial cells in the alveolar...
20.
Zuo W, Rostami M, Shenoy S, LeBlanc M, Salit J, Strulovici-Barel Y, et al.
Respir Res
. 2020 Jul;
21(1):200.
PMID: 32727470
Background: The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the...