Matthew J Shurtleff
Overview
Explore the profile of Matthew J Shurtleff including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
1149
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Recent Articles
1.
Qiu X, Zhang Y, Martin-Rufino J, Weng C, Hosseinzadeh S, Yang D, et al.
Cell
. 2022 Feb;
185(4):690-711.e45.
PMID: 35108499
Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, however, requires kinetic models capable of unveiling governing regulatory...
2.
Temoche-Diaz M, Shurtleff M, Schekman R
Bio Protoc
. 2021 Mar;
10(15):e3706.
PMID: 33659370
Small extracellular vesicles (sEVs) encompass a variety of distinct vesicles that are secreted to the extracellular space. Many methodologies currently used for EV isolation (, differential ultracentrifugation concluding in a...
3.
Miller-Vedam L, Brauning B, Popova K, Schirle Oakdale N, Bonnar J, Prabu J, et al.
Elife
. 2020 Nov;
9.
PMID: 33236988
Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has emerged as a central player in this...
4.
Ngo A, Shurtleff M, Popova K, Kulsuptrakul J, Weissman J, Puschnik A
Elife
. 2019 Sep;
8.
PMID: 31516121
Flaviviruses translate their genomes as multi-pass transmembrane proteins at the endoplasmic reticulum (ER) membrane. Here, we show that the ER membrane protein complex (EMC) is indispensable for the expression of...
5.
Temoche-Diaz M, Shurtleff M, Nottingham R, Yao J, Fadadu R, Lambowitz A, et al.
Elife
. 2019 Aug;
8.
PMID: 31436530
Extracellular vesicles (EVs) encompass a variety of vesicles secreted into the extracellular space. EVs have been implicated in promoting tumor metastasis, but the molecular composition of tumor-derived EV sub-types and...
6.
Shurtleff M, Itzhak D, Hussmann J, Schirle Oakdale N, Costa E, Jonikas M, et al.
Elife
. 2018 May;
7.
PMID: 29809151
The endoplasmic reticulum (ER) supports biosynthesis of proteins with diverse transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane domains such as charged residues in ion channels are often functionally...
7.
Shurtleff M, Yao J, Qin Y, Nottingham R, Temoche-Diaz M, Schekman R, et al.
Proc Natl Acad Sci U S A
. 2017 Oct;
114(43):E8987-E8995.
PMID: 29073095
RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA composition of EVs is challenging due to their coisolation with contaminants, lack of knowledge of the mechanisms...
8.
Shurtleff M, Temoche-Diaz M, Karfilis K, Ri S, Schekman R
Elife
. 2016 Aug;
5.
PMID: 27559612
Exosomes are small vesicles that are secreted from metazoan cells and may convey selected membrane proteins and small RNAs to target cells for the control of cell migration, development and...
9.
Huan J, Hornick N, Shurtleff M, Skinner A, Goloviznina N, Roberts Jr C, et al.
Cancer Res
. 2012 Nov;
73(2):918-29.
PMID: 23149911
Extrinsic signaling cues in the microenvironment of acute myelogenous leukemia (AML) contribute to disease progression and therapy resistance. Yet, it remains unknown how the bone marrow niche in which AML...