Matthew J Shashack
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Explore the profile of Matthew J Shashack including associated specialties, affiliations and a list of published articles.
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4
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20
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Recent Articles
1.
Soto C, Shashack M, Fox R, Bubar M, Rice K, Watson C, et al.
ACS Chem Neurosci
. 2017 Nov;
9(3):514-521.
PMID: 29111677
The 5-HT receptor (5-HTR) plays an important role in various neuropsychiatric disorders, including substance use disorder and schizophrenia. Homodimerization of this receptor has been suggested, but tools that allow direct...
2.
Synthesis and evaluation of dimeric derivatives of 5-HT(2A) receptor (5-HT(2A)R) antagonist M-100907
Shashack M, Cunningham K, Seitz P, McGinnis A, Smith T, Watson C, et al.
ACS Chem Neurosci
. 2012 Jan;
2(11):640-644.
PMID: 22247793
It is now well accepted that at least some serotonin receptors exist in dimeric and oligmeric forms. The linking of receptor ligands has been shown to have potential in the...
3.
Khalaf J, Estrella-Jimenez M, Shashack M, Phatak S, Zhang S, Gilbertson S
ACS Comb Sci
. 2011 Jun;
13(4):351-6.
PMID: 21648460
This paper describes the synthesis of a 300 member library of 3,5-substituted enones. The synthesis starts with 6 different bromoenones that are accessed from the corresponding 1,3 diones. These bromides...
4.
Lory P, Estrella-Jimenez M, Shashack M, Lokesh G, Natarajan A, Gilbertson S
Bioorg Med Chem Lett
. 2007 Sep;
17(21):5940-3.
PMID: 17826998
This manuscript describes methods appropriate for the parallel synthesis of libraries based on the tricyclic thioxanthen-9-one-10,10-dioxide scaffold. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and commercially available 3-carboxylic...