Matthew J McConnell
Overview
Explore the profile of Matthew J McConnell including associated specialties, affiliations and a list of published articles.
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17
Citations
574
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Recent Articles
1.
Ma R, Gong L, Dong C, Utsumi T, Qi J, Zhuang Z, et al.
bioRxiv
. 2025 Feb;
PMID: 39975181
Background: The liver undergoes significant hemodynamic changes during surgery, transplantation, or cirrhosis with portal hypertension(PH). The hepatic artery buffer response(HABR), which compensates for reduced portal venous flow by increasing hepatic...
2.
Jeong J, Hsu S, Horikami D, Utsumi T, Yang Y, Arefyev N, et al.
bioRxiv
. 2025 Jan;
PMID: 39868144
The liver lymphatic system plays a critical role in maintaining interstitial fluid balance and immune regulation. Efficient lymphatic drainage is essential for liver homeostasis, but its role in liver disease...
3.
Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, et al.
JHEP Rep
. 2024 Jul;
6(7):101069.
PMID: 38966234
Background & Aims: The lymphatic system plays crucial roles in maintaining fluid balance and immune regulation. Studying the liver lymphatics has been considered challenging, as common lymphatic endothelial cell (LyEC)...
4.
Tanaka M, Jeong J, Thomas C, Zhang X, Zhang P, Saruwatari J, et al.
Am J Pathol
. 2023 Sep;
193(12):2182-2202.
PMID: 37673329
Liver is the largest lymph-producing organ. In cirrhotic patients, lymph production significantly increases concomitant with lymphangiogenesis. The aim of this study was to determine the mechanism of lymphangiogenesis in liver...
5.
Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, et al.
Am J Physiol Gastrointest Liver Physiol
. 2023 Aug;
325(5):G379-G390.
PMID: 37605828
The liver lymphatic system is essential for maintaining tissue fluid balance and immune function. The detailed structure of lymphatic vessels (LVs) in the liver remains to be fully demonstrated. The...
6.
McConnell M, Iwakiri Y
Curr Hepatol Rep
. 2023 May;
22(2):67-73.
PMID: 37214274
Purpose Of Review: This review article will examine portal hypertension in alcoholic hepatitis (AH) from both a basic mechanistic and a clinical perspective. Recent Findings: Alcoholic hepatitis is a major...
7.
McConnell M, Kostallari E, Ibrahim S, Iwakiri Y
Hepatology
. 2023 Jan;
78(2):649-669.
PMID: 36626620
LSECs are a unique population of endothelial cells within the liver and are recognized as key regulators of liver homeostasis. LSECs also play a key role in liver disease, as...
8.
Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH
Maeda H, Ishima Y, Saruwatari J, Mizuta Y, Minayoshi Y, Ichimizu S, et al.
J Control Release
. 2021 Dec;
341:457-474.
PMID: 34856227
Kupffer cells are a key source of reactive oxygen species (ROS) and are implicated in the development of steatohepatitis and fibrosis in nonalcoholic steatohepatitis (NASH). We recently developed a polythiolated...
9.
McConnell M, Kondo R, Kawaguchi N, Iwakiri Y
Hepatol Commun
. 2021 Oct;
6(2):255-269.
PMID: 34658172
Liver injury, characterized predominantly by elevated aspartate aminotransferase and alanine aminotransferase, is a common feature of coronavirus disease 2019 (COVID-19) symptoms caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Additionally,...
10.
Kondo R, Kawaguchi N, McConnell M, Sonzogni A, Licini L, Valle C, et al.
Hepatol Res
. 2021 Jul;
51(9):1000-1006.
PMID: 34260803
Aim: Coronavirus disease (COVID-19) is characterized by pneumonia with secondary damage to multiple organs including the liver. Liver injury (elevated alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) often correlates with...