Matthew Denholtz
Overview
Explore the profile of Matthew Denholtz including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
928
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0
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Recent Articles
1.
Abujarour R, Dinella J, Pribadi M, Fong L, Denholtz M, Gutierrez A, et al.
Future Sci OA
. 2024 May;
10(1):FSO964.
PMID: 38817352
We explored the generation of human induced pluripotent stem cells (iPSCs) solely through the transcriptional activation of endogenous genes by CRISPR activation (CRISPRa). Minimal number of human-specific guide RNAs targeting...
2.
Goulding J, Yeh W, Hancock B, Blum R, Xu T, Yang B, et al.
Med
. 2023 May;
4(7):457-477.e8.
PMID: 37172578
Background: The advent of chimeric antigen receptor (CAR) T cell therapies has transformed the treatment of hematological malignancies; however, broader therapeutic success of CAR T cells has been limited in...
3.
Zhu Y, Denholtz M, Lu H, Murre C
Genes Dev
. 2020 Dec;
35(1-2):65-81.
PMID: 33334824
During developmental progression the genomes of immune cells undergo large-scale changes in chromatin folding. However, insights into signaling pathways and epigenetic control of nuclear architecture remain rudimentary. Here, we found...
4.
Bortnick A, He Z, Aubrey M, Chandra V, Denholtz M, Chen K, et al.
Cell Rep
. 2020 Jul;
31(13):107876.
PMID: 32610145
No abstract available.
5.
Bortnick A, He Z, Aubrey M, Chandra V, Denholtz M, Chen K, et al.
Cell Rep
. 2020 Apr;
31(1):107470.
PMID: 32268089
The transition from the follicular B to the plasma cell stage is associated with large-scale changes in cell morphology. Here, we examine whether plasma cell development is also associated with...
6.
Denholtz M, Zhu Y, He Z, Lu H, Isoda T, Dohrmann S, et al.
Genes Dev
. 2020 Jan;
34(3-4):149-165.
PMID: 31919189
Differentiating neutrophils undergo large-scale changes in nuclear morphology. How such alterations in structure are established and modulated upon exposure to microbial agents is largely unknown. Here, we found that prior...
7.
Isoda T, Moore A, He Z, Chandra V, Aida M, Denholtz M, et al.
Cell
. 2017 Sep;
171(1):103-119.e18.
PMID: 28938112
It is now established that Bcl11b specifies T cell fate. Here, we show that in developing T cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior. Our...
8.
Zhu Y, Gong K, Denholtz M, Chandra V, Kamps M, Alber F, et al.
Genes Dev
. 2017 Feb;
31(2):141-153.
PMID: 28167501
Neutrophils are responsible for the first line of defense against invading pathogens. Their nuclei are uniquely structured as multiple lobes that establish a highly constrained nuclear environment. Here we found...
9.
Bonora G, Plath K, Denholtz M
Curr Opin Genet Dev
. 2014 Jul;
27:92-101.
PMID: 24998386
The organization of chromatin within the nucleus and the regulation of transcription are tightly linked. Recently, mechanisms underlying this relationship have been uncovered. By defining the organizational hierarchy of the...
10.
Denholtz M, Bonora G, Chronis C, Splinter E, de Laat W, Ernst J, et al.
Cell Stem Cell
. 2013 Sep;
13(5):602-16.
PMID: 24035354
The relationship between 3D organization of the genome and gene-regulatory networks is poorly understood. Here, we examined long-range chromatin interactions genome-wide in mouse embryonic stem cells (ESCs), iPSCs, and fibroblasts...