Matthew C Lorincz
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Explore the profile of Matthew C Lorincz including associated specialties, affiliations and a list of published articles.
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3797
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Recent Articles
11.
Shi H, Strogantsev R, Takahashi N, Kazachenka A, Lorincz M, Hemberger M, et al.
Epigenetics Chromatin
. 2019 Aug;
12(1):49.
PMID: 31399135
Background: KRAB zinc finger proteins (KZFPs) represent one of the largest families of DNA-binding proteins in vertebrate genomes and appear to have evolved to silence transposable elements (TEs) including endogenous...
12.
Xu Q, Xiang Y, Wang Q, Wang L, BrindAmour J, Bogutz A, et al.
Nat Genet
. 2019 May;
51(5):844-856.
PMID: 31040401
The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis. Yet, how it is established remains elusive. Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a...
13.
Au Yeung W, BrindAmour J, Hatano Y, Yamagata K, Feil R, Lorincz M, et al.
Cell Rep
. 2019 Apr;
27(1):282-293.e4.
PMID: 30943408
Mammalian histone methyltransferase G9a (also called EHMT2) deposits H3K9me2 on chromatin and is essential for postimplantation development. However, its role in oogenesis and preimplantation development remains poorly understood. We show...
14.
BrindAmour J, Kobayashi H, Richard Albert J, Shirane K, Sakashita A, Kamio A, et al.
Nat Commun
. 2018 Aug;
9(1):3331.
PMID: 30127397
De novo DNA methylation (DNAme) during mouse oogenesis occurs within transcribed regions enriched for H3K36me3. As many oocyte transcripts originate in long terminal repeats (LTRs), which are heterogeneous even between...
15.
Richard Albert J, Koike T, Younesy H, Thompson R, Bogutz A, Karimi M, et al.
BMC Genomics
. 2018 Jun;
19(1):463.
PMID: 29907088
Background: Allele-specific transcriptional regulation, including of imprinted genes, is essential for normal mammalian development. While the regulatory regions controlling imprinted genes are associated with DNA methylation (DNAme) and specific histone...
16.
17.
Chen C, Goyal P, Karimi M, Abildgaard M, Kimura H, Lorincz M
Genome Res
. 2017 Dec;
28(1):37-51.
PMID: 29229671
Phosphorylation of histone H3 at serine 10 (H3S10ph) by Aurora kinases plays an important role in mitosis; however, H3S10ph also marks regulatory regions of inducible genes in interphase mammalian cells,...
18.
Lorincz M, Schubeler D
Dev Cell
. 2017 Nov;
43(3):257-258.
PMID: 29112847
CpG island promoters are generally devoid of DNA methylation in somatic cells but are frequently methylated during tumorigenesis. Reporting recently in Nature, Smith et al. (2017) show that the signaling-induced...
19.
Wolf G, Rebollo R, Karimi M, Ewing A, Kamada R, Wu W, et al.
Nature
. 2017 Aug;
548(7665):E1-E3.
PMID: 28770848
No abstract available.
20.
Mager D, Lorincz M
Nat Genet
. 2017 Jun;
49(7):974-975.
PMID: 28656984
A study in this issue demonstrates that epigenome-modifying drugs used in cancer chemotherapy induce transcription from thousands of previously unannotated transcription start sites, most of which are derived from ancient...