Matthew C J Yip
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Explore the profile of Matthew C J Yip including associated specialties, affiliations and a list of published articles.
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9
Citations
168
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Recent Articles
1.
Nardone C, Gao J, Seo H, Mintseris J, Ort L, Yip M, et al.
bioRxiv
. 2025 Mar;
PMID: 40027645
The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome complex, revealing how established proteasomal components are...
2.
Crespillo-Casado A, Pothukuchi P, Naydenova K, Yip M, Young J, Boulanger J, et al.
EMBO Rep
. 2024 Oct;
25(11):4979-5005.
PMID: 39375464
Innate immunity senses microbial ligands known as pathogen-associated molecular patterns (PAMPs). Except for nucleic acids, PAMPs are exceedingly taxa-specific, thus enabling pattern recognition receptors to detect cognate pathogens while ignoring...
3.
Coelho J, Yip M, Oltion K, Taunton J, Shao S
Nat Chem Biol
. 2024 Jan;
20(7):877-884.
PMID: 38172604
Translation termination is an essential cellular process, which is also of therapeutic interest for diseases that manifest from premature stop codons. In eukaryotes, translation termination requires eRF1, which recognizes stop...
4.
Yip M, Sedor S, Shao S
Nat Struct Mol Biol
. 2022 Aug;
29(8):774-780.
PMID: 35915257
The E2/E3 enzyme UBE2O ubiquitylates diverse clients to mediate important processes, including targeting unassembled 'orphan' proteins for quality control and clearing ribosomes during erythropoiesis. How quality-control factors, such as UBE2O,...
5.
Morehouse B, Yip M, Keszei A, McNamara-Bordewick N, Shao S, Kranzusch P
Nature
. 2022 Jul;
608(7924):803-807.
PMID: 35859168
Stimulator of interferon genes (STING) is an antiviral signalling protein that is broadly conserved in both innate immunity in animals and phage defence in prokaryotes. Activation of STING requires its...
6.
Keszei A, Yip M, Hsieh T, Shao S
Nat Struct Mol Biol
. 2021 Dec;
28(12):1029-1037.
PMID: 34887561
Close coordination between chaperones is essential for protein biosynthesis, including the delivery of tail-anchored (TA) proteins containing a single C-terminal transmembrane domain to the endoplasmic reticulum (ER) by the conserved...
7.
Yip M, Shao S
Trends Biochem Sci
. 2021 May;
46(9):731-743.
PMID: 33966939
Ribosomes that stall inappropriately during protein synthesis harbor proteotoxic components linked to cellular stress and neurodegenerative diseases. Molecular mechanisms that rescue stalled ribosomes must selectively detect rare aberrant translational complexes...
8.
Yip M, Bodnar N, Rapoport T
Proc Natl Acad Sci U S A
. 2020 Mar;
117(14):7776-7781.
PMID: 32193351
The protein Ddi1 and its homologs in higher eukaryotes have been proposed to serve as shuttling factors that deliver ubiquitinated substrates to the proteasome. Although Ddi1 contains both ubiquitin-interacting UBA...
9.
Yip M, Savickas S, Gygi S, Shao S
Cell Rep
. 2020 Feb;
30(7):2106-2114.e5.
PMID: 32075755
Ribosome-associated quality control (RQC) disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. A key step of RQC is the cleavage of P-site tRNA by the endonuclease...
10.
Yip M, Keszei A, Feng Q, Chu V, McKenna M, Shao S
Nat Struct Mol Biol
. 2019 Apr;
26(5):343-349.
PMID: 31011209
Aberrantly stalled ribosomes initiate the ribosome-associated quality control (RQC) and mRNA surveillance pathways for the degradation of potentially toxic peptides and faulty mRNAs. During RQC, ANKZF1 (yeast Vms1p) releases ubiquitinated...