Mathieu Metifiot
Overview
Explore the profile of Mathieu Metifiot including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
887
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Recent Articles
1.
Bientz L, Guyet U, Guiraud J, Metifiot M, Moulieras M, Aillerie S, et al.
J Glob Antimicrob Resist
. 2024 Dec;
41:44-51.
PMID: 39706477
Carbapenem-resistant Pseudomonas aeruginosa is a global public health concern. IMP-13 is a carbapenemase that was described for the first time in 2001 but is often underestimated due to poor hydrolysis...
2.
Beucher G, Blondot M, Celle A, Pied N, Recordon-Pinson P, Esteves P, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(28):e2202370119.
PMID: 35749382
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract, where infections can...
3.
Got F, Recordon-Pinson P, Loubano-Voumbi G, Ebourombi D, Blondot M, Metifiot M, et al.
Microorganisms
. 2021 Nov;
9(11).
PMID: 34835480
Background: HIV infects around one hundred thousand patients in the Republic of the Congo. Approximately 25% of them receive an antiretroviral treatment; current first-line regimens include two NRTIs and one...
4.
Calmels C, Metifiot M, Andreola M
Biochimie
. 2021 Nov;
195:71-76.
PMID: 34780840
As ZIKV continues to spread, many "unknowns" remain and research is needed to advance the understanding of this important pathogen. Viral RNA dependent-RNA polymerases (RdRp) are validated targets for inhibitors...
5.
Lapaillerie D, Lelandais B, Mauro E, Lagadec F, Tumiotto C, Miskey C, et al.
Nucleic Acids Res
. 2021 Oct;
49(19):11241-11256.
PMID: 34634812
The stable insertion of the retroviral genome into the host chromosomes requires the association between integration complexes and cellular chromatin via the interaction between retroviral integrase and the nucleosomal target...
6.
Torres C, Garling A, Taouji S, Calmels C, Andreola M, Metifiot M
Molecules
. 2021 Sep;
26(17).
PMID: 34500856
Multiple viral targets are now available in the clinic to fight HIV infection. Even if this targeted therapy is highly effective at suppressing viral replication, caregivers are facing growing therapeutic...
7.
Messore A, Corona A, Madia V, Saccoliti F, Tudino V, De Leo A, et al.
J Med Chem
. 2021 Jun;
64(12):8579-8598.
PMID: 34106711
Novel anti-HIV agents are still needed to overcome resistance issues, in particular inhibitors acting against novel viral targets. The ribonuclease H (RNase H) function of the reverse transcriptase (RT) represents...
8.
Messore A, Corona A, Madia V, Saccoliti F, Tudino V, De Leo A, et al.
ACS Med Chem Lett
. 2020 May;
11(5):798-805.
PMID: 32435387
Due to the biological liability of diketo acid (DKA) chain, we transferred this element of our previously reported anti-HIV-1 pyrrolyl derivatives to a non-DKA scaffold, obtaining a series of pyrrolyl-pyrazole...
9.
Aknin C, Smith E, Marchand C, Andreola M, Pommier Y, Metifiot M
Molecules
. 2019 Oct;
24(20).
PMID: 31614773
Currently, an increasing number of drugs are becoming available to clinics for the treatment of HIV infection. Even if this targeted therapy is highly effective at suppressing viral replication, caregivers...
10.
Zhao X, Metifiot M, Kiselev E, Kessl J, Maddali K, Marchand C, et al.
Molecules
. 2018 Jul;
23(8).
PMID: 30049955
HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of...