Mathieu J M Bertrand
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Explore the profile of Mathieu J M Bertrand including associated specialties, affiliations and a list of published articles.
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64
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6934
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Recent Articles
1.
Veli O, Kaya O, Varanda A, Hildebrandt X, Xiao P, Estornes Y, et al.
Mol Metab
. 2024 Jul;
87:101988.
PMID: 39004142
Objective: Receptor-interacting protein kinase 1 (RIPK1) orchestrates the decision between cell survival and cell death in response to tumor necrosis factor (TNF) and other cytokines. Whereas the scaffolding function of...
2.
Rojas-Rivera D, Beltran S, Munoz-Carvajal F, Ahumada-Montalva P, Abarzua L, Gomez L, et al.
Autophagy
. 2024 Jun;
20(11):2444-2459.
PMID: 38873940
Mesenchymal stem cells (MSCs) are used in cell therapy; nonetheless, their application is limited by their poor survival after transplantation in a proinflammatory microenvironment. Macroautophagy/autophagy activation in MSCs constitutes a...
3.
Dondelinger Y, Priem D, Huyghe J, Delanghe T, Vandenabeele P, Bertrand M
Cell Death Dis
. 2023 Nov;
14(11):755.
PMID: 37980412
Plasma membrane permeabilization (PMP) is a defining feature of regulated necrosis. It allows the extracellular release of damage-associated molecular patterns (DAMPs) that trigger sterile inflammation. The pore forming molecules MLKL...
4.
Huyghe J, Priem D, Bertrand M
Trends Immunol
. 2023 Jun;
44(8):628-643.
PMID: 37357102
Tumor necrosis factor (TNF) plays a central role in orchestrating mammalian inflammatory responses. It promotes inflammation either directly by inducing inflammatory gene expression or indirectly by triggering cell death. TNF-mediated...
5.
Vitale I, Pietrocola F, Guilbaud E, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ
. 2023 Apr;
30(5):1097-1154.
PMID: 37100955
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have...
6.
Scarpellini C, Valembois S, Goossens K, Vadi M, Lanthier C, Klejborowska G, et al.
Front Chem
. 2023 Apr;
11:1160164.
PMID: 37090247
Receptor-Interacting serine/threonine-Protein Kinase 1 (RIPK1) emerged as an important driver of inflammation and, consequently, inflammatory pathologies. The enzymatic activity of RIPK1 is known to indirectly promote inflammation by triggering cell...
7.
Van Eeckhoutte H, Donovan C, Kim R, Conlon T, Ansari M, Khan H, et al.
Eur Respir J
. 2022 Dec;
61(4).
PMID: 36549711
Background: Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of regulated cell death (including apoptosis and necroptosis) and inflammation, both drivers of COPD pathogenesis. We aimed to define the...
8.
Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells
Blanchett S, Dondelinger Y, Barbarulo A, Bertrand M, Seddon B
Front Immunol
. 2022 Dec;
13:1067164.
PMID: 36532075
The Inhibitor of Kappa B Kinase (IKK) complex is a critical regulator of NF-κB activation. More recently, IKK has also been shown to repress RIPK1 dependent extrinsic cell death pathways...
9.
Huyghe J, Priem D, Van Hove L, Gilbert B, Fritsch J, Uchiyama Y, et al.
Science
. 2022 Dec;
378(6625):1201-1207.
PMID: 36520901
Cell death induced by tumor necrosis factor (TNF) can be beneficial during infection by helping to mount proper immune responses. However, TNF-induced death can also drive a variety of inflammatory...
10.
van Loo G, Bertrand M
Nat Rev Immunol
. 2022 Nov;
23(5):289-303.
PMID: 36380021
Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory and autoimmune...