Death by TNF: a Road to Inflammation

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2022 Nov 15

PMID 36380021

Authors

Geert van Loo

Mathieu J M Bertrand

Affiliations

Soon will be listed here.

Abstract

Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory and autoimmune pathologies. In recent years, it became clear that TNF drives inflammatory responses not only directly by inducing inflammatory gene expression but also indirectly by inducing cell death, instigating inflammatory immune reactions and disease development. Hence, inhibitors of cell death are being considered as a new therapy for TNF-dependent inflammatory diseases.

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