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Massimo DAgostino

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Articles 28
Citations 264
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Recent Articles
1.
Bonavita R, Di Martino R, Cortone G, Prodomo A, Di Gennaro M, Scerra G, et al.
Front Mol Biosci . 2024 Jul; 11:1420691. PMID: 38993838
Conformational diseases, such as Alzheimer's, Parkinson's and Huntington's diseases as well as ataxias and fronto-temporal disorders, are part of common class of neurological disorders characterised by the aggregation and progressive...
2.
Costanzo M, Cevenini A, Kollipara L, Caterino M, Bianco S, Pirozzi F, et al.
Cell Biosci . 2024 May; 14(1):63. PMID: 38760822
Background: Methylmalonic acidemia (MMA) is a rare inborn error of propionate metabolism caused by deficiency of the mitochondrial methylmalonyl-CoA mutase (MUT) enzyme. As matter of fact, MMA patients manifest impairment...
3.
Scarcella M, Scerra G, Ciampa M, Caterino M, Costanzo M, Rinaldi L, et al.
iScience . 2024 Feb; 27(3):108959. PMID: 38361619
Mucopolysaccharidoses (MPSs) are lysosomal disorders with neurological involvement for which no cure exists. Here, we show that recombinant NK1 fragment of hepatocyte growth factor rescues substrate accumulation and lysosomal defects...
4.
Bianco V, DAgostino M, Pirone D, Giugliano G, Mosca N, di Summa M, et al.
Small Methods . 2023 Sep; 7(11):e2300447. PMID: 37670547
In-flow phase-contrast tomography provides a 3D refractive index of label-free cells in cytometry systems. Its major limitation, as with any quantitative phase imaging approach, is the lack of specificity compared...
5.
Marrone L, DAgostino M, Giordano C, di Giacomo V, Urzini S, Malasomma C, et al.
Oncol Res . 2023 Jul; 31(4):423-436. PMID: 37415743
Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins, immunophilin covers a unique role as 'protein-philin' (Greek...
6.
De Pasquale V, Esposito A, Scerra G, Scarcella M, Ciampa M, Luongo A, et al.
J Med Chem . 2023 Jan; 66(3):1790-1808. PMID: 36696678
Sanfilippo syndrome comprises a group of four genetic diseases due to the lack or decreased activity of enzymes involved in heparan sulfate (HS) catabolism. HS accumulation in lysosomes and other...
7.
Marrone L, DAgostino M, Cesaro E, di Giacomo V, Urzini S, Romano M, et al.
J Cell Biochem . 2023 Jan; 125(12):e30364. PMID: 36645880
FKBP51 is constitutively expressed by immune cells. As other FKBP family members, FKBP51 acts as a coreceptor for the natural products FK506 and rapamycin, which exhibit immunosuppressive effects. However, little...
8.
Caiazza C, Brusco T, DAlessio F, DAgostino M, Avagliano A, Arcucci A, et al.
Int J Mol Sci . 2022 Nov; 23(22). PMID: 36430709
STING is a transmembrane ER resident protein that was initially described as a regulator of innate immune response triggered by viral DNA and later found to be involved in a...
9.
Scerra G, De Pasquale V, Scarcella M, Caporaso M, Pavone L, DAgostino M
Open Biol . 2022 Oct; 12(10):220155. PMID: 36285443
Lysosomal storage diseases (LSDs) comprise a group of inherited monogenic disorders characterized by lysosomal dysfunctions due to undegraded substrate accumulation. They are caused by a deficiency in specific lysosomal hydrolases...
10.
Scerra G, Caporaso M, Renna M, DAgostino M
STAR Protoc . 2021 Nov; 2(4):100916. PMID: 34755119
The lysosomal compartment is a key hub for cell metabolism, and morphological alterations have been described in several pathological conditions. Here, we describe the use of amino acid analogs modified...