Mason A Norgard
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Explore the profile of Mason A Norgard including associated specialties, affiliations and a list of published articles.
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14
Citations
259
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Recent Articles
1.
Zhu X, Potterfield R, Gruber K, Zhang E, Newton S, Norgard M, et al.
J Clin Invest
. 2024 Nov;
135(1).
PMID: 39509261
Cancer patients undergoing chemotherapy often experience anorexia and weight loss that substantially deteriorates overall health, reduces treatment tolerance and quality of life, and worsens oncologic outcomes. There are currently few...
2.
Zhu X, Olson B, Keith D, Norgard M, Levasseur P, Diba P, et al.
Transl Oncol
. 2024 Oct;
50:102129.
PMID: 39353236
Background: The prognosis of pancreatic ductal adenocarcinomas (PDAC) remains very poor, emphasizing the critical importance of early detection, where biomarkers offer unique potential. Although growth differentiation factor 15 (GDF15) and...
3.
Vermehren-Schmaedick A, Joshi S, Wagoner W, Norgard M, Packwood W, Diba P, et al.
Endocrinology
. 2024 Apr;
165(5).
PMID: 38578949
Objectives: Growth factor receptor bound protein 7 (GRB7) is a multidomain signaling adaptor. Members of the Grb7/10/14 family, specifically Gbrb10/14, have important roles in metabolism. We ablated the Grb7 gene...
4.
Huisman C, Norgard M, Levasseur P, Krasnow S, van der Wijst M, Olson B, et al.
Mol Metab
. 2022 Jan;
58:101441.
PMID: 35031523
Objective: Cancer cachexia is a devastating chronic condition characterized by involuntary weight loss, muscle wasting, abnormal fat metabolism, anorexia, and fatigue. However, the molecular mechanisms underlying this syndrome remain poorly...
5.
Proskocil B, Wai K, Lebold K, Norgard M, Michaelis K, De La Torre U, et al.
J Neuroinflammation
. 2021 Sep;
18(1):209.
PMID: 34530852
Background: Toll-like receptor 7 (TLR7) is an innate immune receptor that detects viral single-stranded RNA and triggers the production of proinflammatory cytokines and type 1 interferons in immune cells. TLR7...
6.
Olson B, Zhu X, Norgard M, Diba P, Levasseur P, Buenafe A, et al.
Brain Behav Immun
. 2021 Jul;
97:102-118.
PMID: 34245812
Lipocalin 2 (LCN2) is a pleiotropic molecule that is induced in the central nervous system (CNS) in several acute and chronic pathologies. The acute induction of LCN2 evolved as a...
7.
Olson B, Norgard M, Levasseur P, Zhu X, Marks D
J Cachexia Sarcopenia Muscle
. 2021 Jul;
12(5):1312-1332.
PMID: 34231343
Background: Cancer cachexia is a metabolic disorder characterized by the progressive loss of fat and lean mass that results in significant wasting, ultimately leading to reduced quality of life and...
8.
Olson B, Zhu X, Norgard M, Levasseur P, Butler J, Buenafe A, et al.
Nat Commun
. 2021 Apr;
12(1):2057.
PMID: 33824339
Lipocalin 2 (LCN2) was recently identified as an endogenous ligand of the type 4 melanocortin receptor (MC4R), a critical regulator of appetite. However, it remains unknown if this molecule influences...
9.
Burfeind K, Zhu X, Norgard M, Levasseur P, Huisman C, Buenafe A, et al.
Elife
. 2020 May;
9.
PMID: 32391790
Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular...
10.
Burfeind K, Zhu X, Norgard M, Levasseur P, Huisman C, Michaelis K, et al.
Glia
. 2020 Feb;
68(7):1479-1494.
PMID: 32039522
Microglia in the mediobasal hypothalamus (MBH) respond to inflammatory stimuli and metabolic perturbations to mediate body composition. This concept is well studied in the context of high fat diet induced...