Masaaki Waragai
Overview
Explore the profile of Masaaki Waragai including associated specialties, affiliations and a list of published articles.
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59
Citations
1237
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Recent Articles
1.
Yoshida M, Uemura T, Mizoi M, Waragai M, Sakamoto A, Terui Y, et al.
J Alzheimers Dis
. 2023 Feb;
92(1):361-369.
PMID: 36744340
Background: Dementia, including Alzheimer's disease (AD), is one of the serious diseases at advanced age, and its early detection is important for maintaining quality of life (QOL). Objective: In this...
2.
Ho G, Choo P, Waragai M, Inoue S, Masliah E, Hashimoto M
J Alzheimers Dis Rep
. 2022 May;
6(1):207-210.
PMID: 35591950
Presuming that Alzheimer's disease (AD) might represent an antagonistic pleiotropic phenomenon derived from the evolvability of multiple amyloidogenic proteins, targeting such proteins simultaneously could enhance therapeutic efficacy. Furthermore, considering that...
3.
Homma H, Tanaka H, Jin M, Jin X, Huang Y, Yoshioka Y, et al.
Life Sci Alliance
. 2021 Jun;
4(7).
PMID: 34130995
The early-stage pathologies of frontotemporal lobal degeneration (FTLD) remain largely unknown. In VCP-KI mice carrying VCP gene mutation linked to FTLD, insufficient DNA damage repair in neural stem/progenitor cells (NSCs)...
4.
Hashimoto M, Ho G, Sugama S, Takenouchi T, Waragai M, Sugino H, et al.
J Alzheimers Dis
. 2021 Apr;
81(2):451-458.
PMID: 33814453
Accumulating evidence suggests that the adiponectin (APN) paradox might be involved in promoting aging-associated chronic diseases such as Alzheimer's disease (AD). In human brain, APN regulation of the evolvability of...
5.
Ho G, Takamatsu Y, Wada R, Sugama S, Waragai M, Takenouchi T, et al.
Front Aging Neurosci
. 2020 Nov;
12:576192.
PMID: 33192467
Type 2 diabetes mellitus (T2DM) has been clearlylinked to oxidative stress and amylin amyloidosis in pancreatic β-cells. Yet despite extensive investigation, the biological significance of this is not fully understood....
6.
Waragai M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, et al.
J Alzheimers Dis
. 2020 Jul;
76(4):1249-1253.
PMID: 32623396
Despite the apparent neurotoxicity of amyloid-β (Aβ), recent clinical trials of Aβ immunotherapy have not shown any clinical benefit in Alzheimer's disease (AD). Given this, clarification of the next generation...
7.
Hashimoto M, Ho G, Takamatsu Y, Wada R, Sugama S, Waragai M, et al.
Prion
. 2020 May;
14(1):1-8.
PMID: 32375593
Creutzfeldt-Jackob disease (CJD), the most common human prion disorder, is frequently accompanied by ageing-associated neurodegenerative conditions, such as Alzheimer's disease and Parkinson's disease. Although cross-seeding of amyloidogenic proteins (APs), including...
8.
Waragai M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, et al.
Front Endocrinol (Lausanne)
. 2020 Mar;
11:108.
PMID: 32194507
Adiponectin (APN) is a multi-functional adipokine which sensitizes the insulin signals, stimulates mitochondria biogenesis, and suppresses inflammation. By virtue of these beneficial properties, APN may protect against metabolic syndrome, including...
9.
Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, et al.
Nat Commun
. 2020 Jan;
11(1):507.
PMID: 31980612
The timing and characteristics of neuronal death in Alzheimer's disease (AD) remain largely unknown. Here we examine AD mouse models with an original marker, myristoylated alanine-rich C-kinase substrate phosphorylated at...
10.
Hata S, Omori C, Kimura A, Saito H, Kimura N, Gupta V, et al.
Alzheimers Dement (N Y)
. 2019 Nov;
5:740-750.
PMID: 31754625
Introduction: Neuronal p3-Alcβ peptides are generated from the precursor protein Alcadein β (Alcβ) through cleavage by α- and γ-secretases of the amyloid β (Aβ) protein precursor (APP). To reveal whether...