Mary F Roberts
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Explore the profile of Mary F Roberts including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Roberts M, Gershenson A, Reuter N
Molecules
. 2022 Oct;
27(19).
PMID: 36234717
Phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes are a virulence factor in many Gram-positive organisms. The specific activity of the PI-PLC is significantly increased by adding phosphatidylcholine (PC) to vesicles composed of...
2.
Roberts M, Hedstrom L
Front Mol Biosci
. 2022 Apr;
9:865519.
PMID: 35433832
The dynamic interactions of enzymes and substrates underpins catalysis, yet few techniques can interrogate the dynamics of protein-bound ligands. Here we describe the use of field cycling NMR relaxometry to...
3.
Moutoussamy E, Khan H, Roberts M, Gershenson A, Chipot C, Reuter N
J Chem Inf Model
. 2022 Mar;
62(24):6602-6613.
PMID: 35343689
Peripheral membrane proteins (PMPs) bind temporarily to cellular membranes and play important roles in signaling, lipid metabolism, and membrane trafficking. Obtaining accurate membrane-PMP affinities using experimental techniques is more challenging...
4.
Roberts M, Cai J, V Natarajan S, Khan H, Reuter N, Gershenson A, et al.
J Phys Chem B
. 2021 Jul;
125(31):8827-8838.
PMID: 34320805
Diverse phospholipid motions are key to membrane function but can be quite difficult to untangle and quantify. High-resolution field cycling P NMR spin-lattice relaxometry, where the sample is excited at...
5.
Rosenberg M, Yao T, Patton G, Redfield A, Roberts M, Hedstrom L
Biochemistry
. 2020 Jun;
59(25):2359-2370.
PMID: 32479091
The remarkable power and specificity of enzyme catalysis rely on the dynamic alignment of the enzyme, substrates, and cofactors, yet the role of dynamics has usually been approached from the...
6.
Roberts M, Khan H, Goldstein R, Reuter N, Gershenson A
Chem Rev
. 2018 Aug;
118(18):8435-8473.
PMID: 30148347
Phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes from Gram-positive bacteria are secreted virulence factors that aid in downregulating host immunity. These PI-PLCs are minimalist peripheral membrane enzymes with a distorted (βα) TIM...
7.
Rosenberg M, Redfield A, Roberts M, Hedstrom L
Biochemistry
. 2018 Mar;
57(22):3146-3154.
PMID: 29547266
The ability of enzymes to modulate the dynamics of bound substrates and cofactors is a critical feature of catalysis, but the role of dynamics has largely been approached from the...
8.
Roberts D, Yang Y, Morettin C, Newman T, Roberts M, Wilensky J
Anat Rec (Hoboken)
. 2017 Feb;
300(7):1336-1347.
PMID: 28196403
People with the long anterior zonule (LAZ) trait, which may have prevalence near 2%, have zonular fibers that extend more central than usual along the anterior capsule of the crystalline...
9.
Roberts M
Structure
. 2017 Jan;
25(1):3-4.
PMID: 28052237
The Aichi RNA virus remodels host membranes by conscripting two host proteins, PI4KIIIβ (to generate PI4P in the remodeled vesicle) and ACBD3 (that tightly binds PI4KIIIβ), and localizing them on...
10.
Rosenberg M, Redfield A, Roberts M, Hedstrom L
J Biol Chem
. 2016 Sep;
291(44):22988-22998.
PMID: 27613871
Guanosine-5'-monophosphate reductase (GMPR) catalyzes the reduction of GMP to IMP and ammonia with concomitant oxidation of NADPH. Here we investigated the structure and dynamics of enzyme-bound substrates and cofactors by...