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Martin Y H Zhang

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Articles 11
Citations 519
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Recent Articles
1.
Egli-Spichtig D, Zhang M, Li A, Pastor Arroyo E, Hernando N, Wagner C, et al.
Sci Rep . 2021 Mar; 11(1):6175. PMID: 33731726
Fibroblast growth factor 23 (FGF23) is a bone-derived endocrine hormone that regulates phosphate and vitamin D metabolism. In models of FGF23 excess, renal deoxyribonuclease 1 (Dnase1) mRNA expression is downregulated....
2.
Egli-Spichtig D, Imenez Silva P, Glaudemans B, Gehring N, Bettoni C, Zhang M, et al.
Kidney Int . 2019 Jul; 96(4):890-905. PMID: 31301888
Fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis, and its early rise in patients with chronic kidney disease is independently associated with all-cause mortality. Since inflammation is characteristic of chronic...
3.
Egli-Spichtig D, Zhang M, Perwad F
Front Physiol . 2018 Nov; 9:1494. PMID: 30405444
Fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis and vitamin D metabolism. In patients with acute kidney injury (AKI), FGF23 levels rise rapidly after onset of AKI and are associated...
4.
Portale A, Zhang M, David V, Martin A, Jiao Y, Gu W, et al.
PLoS One . 2015 Nov; 10(11):e0142924. PMID: 26588476
Fibroblast growth factor 23 (FGF23) is a potent regulator of phosphate (Pi) and vitamin D homeostasis. The transcription factor, early growth response 1 (egr-1), is a biomarker for FGF23-induced activation...
5.
Chanakul A, Zhang M, Louw A, Armbrecht H, Miller W, Portale A, et al.
PLoS One . 2013 Sep; 8(9):e72816. PMID: 24019880
The mitochondrial enzyme 25-hydroxyvitamin D 1α-hydroxylase, which is encoded by the CYP27B1 gene, converts 25OHD to the biological active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D). Renal 1α-hydroxylase activity is...
6.
Zhang M, Ranch D, Pereira R, Armbrecht H, Portale A, Perwad F
Endocrinology . 2012 Feb; 153(4):1806-16. PMID: 22334725
The X-linked hypophosphatemic (Hyp) mouse carries a loss-of-function mutation in the phex gene and is characterized by hypophosphatemia due to renal phosphate (Pi) wasting, inappropriately suppressed 1,25-dihydroxyvitamin D [1,25(OH)₂D] production,...
7.
Perwad F, Zhang M, Tenenhouse H, Portale A
Am J Physiol Renal Physiol . 2007 Aug; 293(5):F1577-83. PMID: 17699549
Fibroblast growth factor-23 (FGF-23) is critical to the pathogenesis of a distinct group of renal phosphate wasting disorders: tumor-induced osteomalacia, X-linked hypophosphatemia, and autosomal dominant and autosomal recessive hypophosphatemic rickets....
8.
Perwad F, Azam N, Zhang M, Yamashita T, Tenenhouse H, Portale A
Endocrinology . 2005 Aug; 146(12):5358-64. PMID: 16123154
Fibroblast growth factor-23 (FGF-23) is a novel circulating peptide that regulates phosphorus (Pi) and vitamin D metabolism, but the mechanisms by which circulating FGF-23 itself is regulated are unknown. To...
9.
Azam N, Zhang M, Wang X, Tenenhouse H, Portale A
Endocrinology . 2003 Jul; 144(8):3463-8. PMID: 12865326
X-linked hypophosphatemic (Hyp) mice exhibit hypophosphatemia, impaired renal phosphate reabsorption, defective skeletal mineralization, and disordered regulation of vitamin D metabolism: In Hyp mice, restriction of dietary phosphorus induces a decrease...
10.
Wang X, Zhang M, Miller W, Portale A
J Clin Endocrinol Metab . 2002 Jun; 87(6):2424-30. PMID: 12050193
The rate-limiting, hormonally regulated step in the biological activation of vitamin D is its 1alpha-hydroxylation to 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] in the kidney, catalyzed by the mitochondrial cytochrome P450 enzyme, P450c1alpha....