Martin Schleef
Overview
Explore the profile of Martin Schleef including associated specialties, affiliations and a list of published articles.
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37
Citations
465
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Recent Articles
11.
Grisch-Chan H, Schlegel A, Scherer T, Allegri G, Heidelberger R, Tsikrika P, et al.
Mol Ther Nucleic Acids
. 2017 Jun;
7:339-349.
PMID: 28624210
Limited duration of transgene expression, insertional mutagenesis, and size limitations for transgene cassettes pose challenges and risk factors for many gene therapy vectors. Here, we report on physiological expression of...
12.
Schnodt M, Schmeer M, Kracher B, Krusemann C, Espinosa L, Grunert A, et al.
Mol Ther Nucleic Acids
. 2017 Jan;
5:e355.
PMID: 28131313
Adeno-associated viral (AAV) vectors are considered as one of the most promising delivery systems in human gene therapy. In addition, AAV vectors are frequently applied tools in preclinical and basic...
13.
Hudecek M, Gogishvili T, Monjezi R, Wegner J, Shankar R, Kruesemann C, et al.
Recent Results Cancer Res
. 2017 Jan;
209:37-50.
PMID: 28101686
Plasmid DNA is being used as a pharmaceutical agent in vaccination, as well as a basic substance and starting material in gene and cell therapy, and viral vector production. Since...
14.
Bazzani R, Pringle I, Connolly M, Davies L, Sumner-Jones S, Schleef M, et al.
Biomaterials
. 2016 Apr;
93:20-26.
PMID: 27061267
Non-viral aerosol gene therapy offers great potential for treating chronic lung diseases of the airways such as cystic fibrosis (CF). Early clinical trials showed that transgene expression in the airways...
15.
Gruenert A, Czugala M, Mueller C, Schmeer M, Schleef M, Kruse F, et al.
PLoS One
. 2016 Mar;
11(3):e0152589.
PMID: 27023329
Transplantation of a donor cornea to restore vision is the most frequently performed transplantation in the world. Corneal endothelial cells (CEC) are crucial for the outcome of a graft as...
16.
Garrels W, Talluri T, Ziegler M, Most I, Forcato D, Schmeer M, et al.
Biotechnol J
. 2015 Oct;
11(1):178-84.
PMID: 26470758
Transgenesis in the mouse is an essential tool for the understanding of gene function and genome organization. Here, we describe a simplified microinjection protocol for efficient germline transgenesis and sustained...
17.
Freudenau I, Lutter P, Baier R, Schleef M, Bednarz H, Lara A, et al.
Front Bioeng Biotechnol
. 2015 Sep;
3:127.
PMID: 26389114
Plasmids have become very important as pharmaceutical gene vectors in the fields of gene therapy and genetic vaccination in the past years. In this study, we present a dynamic model...
18.
Schleef M, Schirmbeck R, Reiser M, Michel M, Schmeer M
Methods Mol Biol
. 2015 Jun;
1317:327-39.
PMID: 26072415
The use of DNA vaccines requires pharmaceutical grade DNA that causes the immunization on the basis of a nucleic acid sequence that encodes the protein to be vaccinated against. This...
19.
Schmeer M, Schleef M
Methods Mol Biol
. 2015 Jun;
1317:315-26.
PMID: 26072414
Pharmaceutical applications of plasmid DNA require certain quality standards, depending on the intended use of the plasmids. That is, for direct gene transfer into human, GMP Grade is mandatory, however,...
20.
Akita H, Kurihara D, Schmeer M, Schleef M, Harashima H
Pharmaceutics
. 2015 Jun;
7(2):64-73.
PMID: 26066769
The nuclear transfer process is one of the critical rate-limiting processes in transgene expression. In the present study, we report on the effect of compaction and the size of the...