Martin Mikl
Overview
Explore the profile of Martin Mikl including associated specialties, affiliations and a list of published articles.
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13
Citations
314
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Recent Articles
1.
Loughran G, Andreev D, Terenin I, Namy O, Mikl M, Yordanova M, et al.
Nat Struct Mol Biol
. 2025 Mar;
PMID: 40033152
Dual reporters encoding two distinct proteins within the same mRNA have had a crucial role in identifying and characterizing unconventional mechanisms of eukaryotic translation. These mechanisms include initiation via internal...
2.
Hartal-Benishay L, Tal S, Elkader A, Ehsainieh O, Srouji-Eid R, Lavy T, et al.
iScience
. 2024 Dec;
27(12):111403.
PMID: 39687029
Cyclooxygenase-2 (COX-2) catalyzes the oxidation of arachidonic acid (AA) into a single product that is the source of all prostaglandins (PGs), ligands of multiple pro-inflammatory pathways. AA catalysis results in...
3.
Rosenberg M, Greenstein E, Buchkovich M, Peres A, Santoni-Rugiu E, Yang L, et al.
Cell Rep
. 2023 Aug;
42(8):112879.
PMID: 37537844
Neuroblastoma is a lethal childhood solid tumor of developing peripheral nerves. Two percent of children with neuroblastoma develop opsoclonus myoclonus ataxia syndrome (OMAS), a paraneoplastic disease characterized by cerebellar and...
4.
A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing
Isaac R, Vinik Y, Mikl M, Nadav-Eliyahu S, Shatz-Azoulay H, Yaakobi A, et al.
iScience
. 2022 Oct;
25(11):105270.
PMID: 36304109
The seven-transmembrane superfamily member 3 protein (TM7SF3) is a p53-regulated homeostatic factor that attenuates cellular stress and the unfolded protein response. Here we show that TM7SF3 localizes to nuclear speckles;...
5.
Mikl M, Eletto D, Nijim M, Lee M, Lafzi A, Mhamedi F, et al.
Nucleic Acids Res
. 2022 Sep;
50(18):10643-10664.
PMID: 36156153
Asymmetric subcellular mRNA localization allows spatial regulation of gene expression and functional compartmentalization. In neurons, localization of specific mRNAs to neurites is essential for cellular functioning. However, it is largely...
6.
Mikl M, Pilpel Y, Segal E
Nat Commun
. 2020 Jun;
11(1):3061.
PMID: 32546731
Programmed ribosomal frameshifting (PRF) is the controlled slippage of the translating ribosome to an alternative frame. This process is widely employed by human viruses such as HIV and SARS coronavirus...
7.
Zuckerman B, Ron M, Mikl M, Segal E, Ulitsky I
Mol Cell
. 2020 Jun;
79(2):251-267.e6.
PMID: 32504555
The core components of the nuclear RNA export pathway are thought to be required for export of virtually all polyadenylated RNAs. Here, we depleted different proteins that act in nuclear...
8.
Mikl M, Hamburg A, Pilpel Y, Segal E
Nat Commun
. 2019 Oct;
10(1):4572.
PMID: 31594945
Most human genes are alternatively spliced, allowing for a large expansion of the proteome. The multitude of regulatory inputs to splicing limits the potential to infer general principles from investigating...
9.
Jagut M, Hamminger P, Woglar A, Millonigg S, Paulin L, Mikl M, et al.
PLoS Biol
. 2016 Mar;
14(3):e1002412.
PMID: 27011106
During the first meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation. COs are produced by homologous recombination (HR)-mediated repair of programmed DNA double strand breaks (DSBs). As...
10.
Mikl M, Cowan C
Cell Rep
. 2014 Sep;
8(5):1380-90.
PMID: 25199833
Cell polarity in one-cell C. elegans embryos guides asymmetric cell division and cell-fate specification. Shortly after fertilization, embryos establish two antagonistic cortical domains of PAR proteins. Here, we find that...