Martin Machyna
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Explore the profile of Martin Machyna including associated specialties, affiliations and a list of published articles.
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16
Citations
400
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Recent Articles
1.
Vock I, Mabin J, Machyna M, Zhang A, Hogg J, Simon M
bioRxiv
. 2024 Oct;
PMID: 39463977
Nucleotide recoding RNA sequencing methods (NR-seq; TimeLapse-seq, SLAM-seq, TUC-seq, etc.) are powerful approaches for assaying transcript population dynamics. In addition, these methods have been extended to probe a host of...
2.
Bulashevska A, Nacsa Z, Lang F, Braun M, Machyna M, Diken M, et al.
Front Immunol
. 2024 Jun;
15:1394003.
PMID: 38868767
Cancer immunotherapy has witnessed rapid advancement in recent years, with a particular focus on neoantigens as promising targets for personalized treatments. The convergence of immunogenomics, bioinformatics, and artificial intelligence (AI)...
3.
Hufsky F, Abecasis A, Babaian A, Beck S, Brierley L, Dellicour S, et al.
Viruses
. 2023 Oct;
15(10).
PMID: 37896809
The 2023 International Virus Bioinformatics Meeting was held in Valencia, Spain, from 24-26 May 2023, attracting approximately 180 participants worldwide. The primary objective of the conference was to establish a...
4.
Lu-Culligan W, Connor L, Xie Y, Ekundayo B, Rose B, Machyna M, et al.
Nature
. 2023 Sep;
622(7981):173-179.
PMID: 37731000
Lysine residues in histones and other proteins can be modified by post-translational modifications that encode regulatory information. Lysine acetylation and methylation are especially important for regulating chromatin and gene expression....
5.
Courchaine E, Gelles-Watnick S, Machyna M, Straube K, Sauyet S, Enright J, et al.
Nat Commun
. 2022 Oct;
13(1):6005.
PMID: 36224177
Cajal bodies (CBs) are ubiquitous nuclear membraneless organelles (MLOs) that concentrate and promote efficient biogenesis of snRNA-protein complexes involved in splicing (snRNPs). Depletion of the CB scaffolding protein coilin disperses...
6.
Biancon G, Joshi P, Zimmer J, Hunck T, Gao Y, Lessard M, et al.
Mol Cell
. 2022 Mar;
82(6):1107-1122.e7.
PMID: 35303483
Splicing factor mutations are common among cancers, recently emerging as drivers of myeloid malignancies. U2AF1 carries hotspot mutations in its RNA-binding motifs; however, how they affect splicing and promote cancer...
7.
Machyna M, Kiefer L, Simon M
Nat Struct Mol Biol
. 2020 Mar;
27(4):400.
PMID: 32203493
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Machyna M, Kiefer L, Simon M
Nat Struct Mol Biol
. 2020 Mar;
27(3):297-304.
PMID: 32157249
Understanding the targeting and spreading patterns of long non-coding RNAs (lncRNAs) on chromatin requires a technique that can detect both high-intensity binding sites and reveal genome-wide changes in spreading patterns...
9.
Simon M, Machyna M
Cold Spring Harb Perspect Biol
. 2019 Nov;
11(11).
PMID: 31676573
The diverse roles of cellular RNAs can be studied by purifying RNAs of interest together with the biomolecules they bind. Biotinylated antisense oligonucleotides that hybridize specifically to the RNA of...
10.
Machyna M, Simon M
Brief Funct Genomics
. 2017 Nov;
17(2):96-103.
PMID: 29126220
The growing appreciation of the importance of long noncoding RNAs (lncRNAs), together with the awareness that some of these RNAs are associated with chromatin, has inspired the development of methods...