Martin Leeb
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Explore the profile of Martin Leeb including associated specialties, affiliations and a list of published articles.
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30
Citations
1786
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Recent Articles
1.
Santini L, Kowald S, Cerron-Alvan L, Huth M, Fabing A, Sestini G, et al.
Nat Commun
. 2024 Sep;
15(1):7879.
PMID: 39251582
Naïve pluripotency is sustained by a self-reinforcing gene regulatory network (GRN) comprising core and naïve pluripotency-specific transcription factors (TFs). Upon exiting naïve pluripotency, embryonic stem cells (ESCs) transition through a...
2.
Lando D, Ma X, Cao Y, Jartseva A, Stevens T, Boucher W, et al.
Mol Cell
. 2024 Mar;
84(8):1406-1421.e8.
PMID: 38490199
Enhancers bind transcription factors, chromatin regulators, and non-coding transcripts to modulate the expression of target genes. Here, we report 3D genome structures of single mouse ES cells as they are...
3.
Ferlazzo G, Gambetta A, Amato S, Cannizzaro N, Angiolillo S, Arboit M, et al.
Nat Commun
. 2023 Jul;
14(1):3962.
PMID: 37407555
Huntington's disease (HD) is a neurodegenerative disorder caused by CAG-repeat expansions in the huntingtin (HTT) gene. The resulting mutant HTT (mHTT) protein induces toxicity and cell death via multiple mechanisms...
4.
Hill L, Jaritz M, Tagoh H, Schindler K, Kostanova-Poliakova D, Sun Q, et al.
EMBO J
. 2023 Jun;
42(15):e112741.
PMID: 37337907
While extended loop extrusion across the entire Igh locus controls V -DJ recombination, local regulatory sequences, such as the PAIR elements, may also activate V gene recombination in pro-B-cells. Here,...
5.
Huth M, Santini L, Galimberti E, Ramesmayer J, Titz-Teixeira F, Sehlke R, et al.
Genes Dev
. 2022 Mar;
36(5-6):348-367.
PMID: 35241478
Cell fate transitions depend on balanced rewiring of transcription and translation programs to mediate ordered developmental progression. Components of the nonsense-mediated mRNA decay (NMD) pathway have been implicated in regulating...
6.
Appel L, Franke V, Bruno M, Grishkovskaya I, Kasiliauskaite A, Kaufmann T, et al.
Nat Commun
. 2021 Oct;
12(1):6078.
PMID: 34667177
The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a regulatory hub for transcription and RNA processing. Here, we identify PHD-finger protein 3 (PHF3)...
7.
Santini L, Halbritter F, Titz-Teixeira F, Suzuki T, Asami M, Ma X, et al.
Nat Commun
. 2021 Jun;
12(1):3804.
PMID: 34155196
In mammalian genomes, differentially methylated regions (DMRs) and histone marks including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are asymmetrically inherited to control parentally-biased gene expression. However,...
8.
Lackner A, Sehlke R, Garmhausen M, Stirparo G, Huth M, Titz-Teixeira F, et al.
EMBO J
. 2021 Mar;
40(8):e105776.
PMID: 33687089
In the mammalian embryo, epiblast cells must exit the naïve state and acquire formative pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells (ESCs), which undergo pluripotency...
9.
Thomas H, Kotova E, Jayaram S, Pilz A, Romeike M, Lackner A, et al.
Mol Cell
. 2021 Jan;
81(5):969-982.e13.
PMID: 33482114
Many genes are regulated by multiple enhancers that often simultaneously activate their target gene. However, how individual enhancers collaborate to activate transcription is not well understood. Here, we dissect the...
10.
Lando D, Basu S, Stevens T, Riddell A, Wohlfahrt K, Cao Y, et al.
Nat Protoc
. 2018 Apr;
13(5):1034-1061.
PMID: 29674753
Fluorescence imaging and chromosome conformation capture assays such as Hi-C are key tools for studying genome organization. However, traditionally, they have been carried out independently, making integration of the two...