Martin L Kramer
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Explore the profile of Martin L Kramer including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
102
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0
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Recent Articles
1.
Boddupalli C, Nair S, Belinsky G, Gans J, Teeple E, Nguyen T, et al.
Elife
. 2022 Aug;
11.
PMID: 35972072
Background: Neuronopathic Gaucher disease (nGD) is a rare neurodegenerative disorder caused by biallelic mutations in and buildup of glycosphingolipids in lysosomes. Neuronal injury and cell death are prominent pathological features;...
2.
Wang H, Davison M, Kramer M, Qiu W, Gladysheva T, Chiang R, et al.
Cells
. 2022 Mar;
11(5).
PMID: 35269535
Cerebral adrenoleukodystrophy (CALD) is a devastating, demyelinating neuroinflammatory manifestation found in up to 40% of young males with an inherited mutation in , the causative gene in adrenoleukodystrophy. The search...
3.
Skerlj R, Bastos C, Booker M, Kramer M, Barker Jr R, Celatka C, et al.
ACS Med Chem Lett
. 2014 Jun;
2(9):708-13.
PMID: 24900364
Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum...
4.
Crowther G, Booker M, He M, Li T, Raverdy S, Novelli J, et al.
PLoS Negl Trop Dis
. 2014 Jan;
8(1):e2628.
PMID: 24416464
Cofactor-independent phosphoglycerate mutase (iPGAM) is essential for the growth of C. elegans but is absent from humans, suggesting its potential as a drug target in parasitic nematodes such as Brugia...
5.
Booker M, Bastos C, Kramer M, Barker Jr R, Skerlj R, Sidhu A, et al.
J Biol Chem
. 2010 Aug;
285(43):33054-33064.
PMID: 20702404
Plasmodium falciparum, the causative agent of the most deadly form of human malaria, is unable to salvage pyrimidines and must rely on de novo biosynthesis for survival. Dihydroorotate dehydrogenase (DHODH)...