Martin K Ostermaier
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Explore the profile of Martin K Ostermaier including associated specialties, affiliations and a list of published articles.
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10
Citations
216
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Recent Articles
1.
Yorulmaz Avsar S, Kapinos L, Schoenenberger C, Schertler G, Muhle J, Meger B, et al.
Phys Chem Chem Phys
. 2020 Oct;
22(41):24086-24096.
PMID: 33079118
G protein-coupled receptors (GPCRs) are a large and ubiquitous family of membrane receptors of great pharmacological interest. Cell-based assays are the primary tool for assessing GPCR interactions and activation but...
2.
Haider R, Wilhelm F, Rizk A, Mutt E, Deupi X, Peterhans C, et al.
Sci Rep
. 2019 Jan;
9(1):439.
PMID: 30679635
Arrestin-1 desensitizes the activated and phosphorylated photoreceptor rhodopsin by forming transient rhodopsin-arrestin-1 complexes that eventually decay to opsin, retinal and arrestin-1. Via a multi-dimensional screening setup, we identified and combined...
3.
Peterhans C, Lally C, Ostermaier M, Sommer M, Standfuss J
Sci Rep
. 2016 Jul;
6:30224.
PMID: 27443887
No abstract available.
4.
Peterhans C, Lally C, Ostermaier M, Sommer M, Standfuss J
Sci Rep
. 2016 Jun;
6:28686.
PMID: 27350090
Arrestins desensitize G protein-coupled receptors (GPCRs) and act as mediators of signalling. Here we investigated the interactions of arrestin-1 with two functionally distinct forms of the dim-light photoreceptor rhodopsin. Using...
5.
Ostermaier M, Schertler G, Standfuss J
Curr Opin Struct Biol
. 2014 Dec;
29:143-51.
PMID: 25484000
The past years have seen tremendous progress towards understanding how arrestins recognize phosphorylated G protein-coupled receptors (GPCRs). Two arrestin crystal structures, one of a pre-activated splice variant and one bound...
6.
Ostermaier M, Peterhans C, Jaussi R, Deupi X, Standfuss J
Proc Natl Acad Sci U S A
. 2014 Jan;
111(5):1825-30.
PMID: 24449856
Arrestins function as adapter proteins that mediate G protein-coupled receptor (GPCR) desensitization, internalization, and additional rounds of signaling. Here we have compared binding of the GPCR rhodopsin to 403 mutants...
7.
Sun D, Ostermaier M, Heydenreich F, Mayer D, Jaussi R, Standfuss J, et al.
PLoS One
. 2013 Nov;
8(10):e78878.
PMID: 24205336
Scanning mutagenesis is a powerful protein engineering technique used to study protein structure-function relationship, map binding sites and design more stable proteins or proteins with altered properties. One of the...
8.
Vishnivetskiy S, Ostermaier M, Singhal A, Panneels V, Homan K, Glukhova A, et al.
Cell Signal
. 2013 Jul;
25(11):2155-62.
PMID: 23872075
The effects of activating mutations associated with night blindness on the stoichiometry of rhodopsin interactions with G protein-coupled receptor kinase 1 (GRK1) and arrestin-1 have not been reported. Here we...
9.
Singhal A, Ostermaier M, Vishnivetskiy S, Panneels V, Homan K, Tesmer J, et al.
EMBO Rep
. 2013 Apr;
14(6):520-6.
PMID: 23579341
We present active-state structures of the G protein-coupled receptor (GPCRs) rhodopsin carrying the disease-causing mutation G90D. Mutations of G90 cause either retinitis pigmentosa (RP) or congenital stationary night blindness (CSNB),...
10.
Albert B, Leger-Silvestre I, Normand C, Ostermaier M, Perez-Fernandez J, Panov K, et al.
J Cell Biol
. 2011 Jan;
192(2):277-93.
PMID: 21263028
RNA polymerase I (Pol I) produces large ribosomal RNAs (rRNAs). In this study, we show that the Rpa49 and Rpa34 Pol I subunits, which do not have counterparts in Pol...