Martin C Wapenaar
Overview
Explore the profile of Martin C Wapenaar including associated specialties, affiliations and a list of published articles.
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16
Citations
786
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Recent Articles
1.
Romanos J, Rybak A, Wijmenga C, Wapenaar M
Expert Opin Med Diagn
. 2013 Mar;
2(4):399-416.
PMID: 23495707
Background: Celiac disease (CD) is a complex genetic disorder of the small intestine resulting from aberrant cellular responses to gluten peptides. It may affect as much as 1% of the...
2.
Szperl A, Golachowska M, Bruinenberg M, Prekeris R, Thunnissen A, Karrenbeld A, et al.
J Pediatr Gastroenterol Nutr
. 2011 Jan;
52(3):307-13.
PMID: 21206382
Objectives: Microvillus inclusion disease (MVID) is a rare autosomal recessive enteropathy characterized by intractable diarrhea and malabsorption. Recently, various MYO5B gene mutations have been identified in patients with MVID. Interestingly,...
3.
Wolters V, Alizadeh B, Weijerman M, Zhernakova A, van Hoogstraten I, Mearin M, et al.
Hum Immunol
. 2010 Jan;
71(4):392-6.
PMID: 20096742
Various genes may influence intestinal barrier function, including MAGI2, MYO9B, and PARD3, which are associated with celiac disease. Because direct measurement of intestinal permeability is difficult, antibodies against gliadin (AGA)...
4.
Festen E, Szperl A, Weersma R, Wijmenga C, Wapenaar M
Endocr Metab Immune Disord Drug Targets
. 2009 Jun;
9(2):199-218.
PMID: 19519468
Inflammatory bowel disease, which covers Crohn's disease and ulcerative colitis, and celiac disease are both inflammatory diseases of the intestinal tract. In both diseases an antigen activates several inflammatory pathways,...
5.
Hunt K, Zhernakova A, Turner G, Heap G, Franke L, Bruinenberg M, et al.
Nat Genet
. 2008 Mar;
40(4):395-402.
PMID: 18311140
Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA markers...
6.
van Heel D, Franke L, Hunt K, Gwilliam R, Zhernakova A, Inouye M, et al.
Nat Genet
. 2007 Jun;
39(7):827-9.
PMID: 17558408
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was...
7.
Diosdado B, van Bakel H, Strengman E, Franke L, van Oort E, Mulder C, et al.
Clin Gastroenterol Hepatol
. 2007 Mar;
5(5):574-81.
PMID: 17336591
Background & Aims: Celiac disease is an enteropathy featuring villous atrophy, crypt hyperplasia, and lymphocytosis. Tissue remodeling is driven by an inflammatory reaction to gluten in genetically susceptible individuals. The...
8.
Wapenaar M, Monsuur A, Poell J, van t Slot R, Meijer J, Meijer G, et al.
Immunogenetics
. 2007 Mar;
59(5):349-57.
PMID: 17333166
The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). Our aim was to assess the gut mucosal...
9.
Curley C, Monsuur A, Wapenaar M, Rioux J, Wijmenga C
Eur J Hum Genet
. 2006 Jul;
14(11):1215-22.
PMID: 16835590
It is increasingly evident that different inflammatory disorders show some overlap in their pathological features, concurrence in families and individuals, and shared genetic factors. This might also be true for...
10.
Amundsen S, Monsuur A, Wapenaar M, Lie B, Ek J, Gudjonsdottir A, et al.
Hum Immunol
. 2006 May;
67(4-5):341-5.
PMID: 16720215
Association between myosin IXB (MYO9B) gene variants and celiac disease (CD) has been reported in a study of a Dutch cohort. Six single nucleotide polymorphisms (SNPs) within the 3' part...