Martin Bushell
Overview
Explore the profile of Martin Bushell including associated specialties, affiliations and a list of published articles.
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Articles
83
Citations
4337
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Recent Articles
31.
Bader A, Bushell M
Cell Death Dis
. 2020 Apr;
11(4):280.
PMID: 32332801
The recent discovery of DNA:RNA hybrids, or R-loops, actively forming at DNA double-strand breaks (DSBs) has unlocked fresh insight into how RNA participates in DNA repair. However, the manner of...
32.
Bader A, Hawley B, Wilczynska A, Bushell M
Br J Cancer
. 2020 Jan;
122(5):613-623.
PMID: 31894141
Effective DNA repair is essential for cell survival: a failure to correctly repair damage leads to the accumulation of mutations and is the driving force for carcinogenesis. Multiple pathways have...
33.
Waldron J, Tack D, Ritchey L, Gillen S, Wilczynska A, Turro E, et al.
Genome Biol
. 2020 Jan;
20(1):300.
PMID: 31888698
Background: The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting...
34.
Wilczynska A, Gillen S, Schmidt T, Meijer H, Jukes-Jones R, Langlais C, et al.
Genome Biol
. 2019 Dec;
20(1):262.
PMID: 31791371
Background: Regulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research,...
35.
Meijer H, Schmidt T, Gillen S, Langlais C, Jukes-Jones R, de Moor C, et al.
Nucleic Acids Res
. 2019 Jun;
47(15):8224-8238.
PMID: 31180491
The CCR4-NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the...
36.
Skalka G, Hall H, Somers J, Bushell M, Willis A, Malewicz M
Cell Cycle
. 2019 Apr;
18(9):963-975.
PMID: 30973299
Common hallmarks of cancer include the dysregulation of cell cycle progression and the acquisition of genome instability. In tumors, G1 cell cycle checkpoint induction is often lost. This increases the...
37.
Marini A, Rotblat B, Sbarrato T, Niklison-Chirou M, Knight J, Dudek K, et al.
Proc Natl Acad Sci U S A
. 2018 May;
115(24):6219-6224.
PMID: 29844156
TAp73 is a transcription factor that plays key roles in brain development, aging, and cancer. At the cellular level, TAp73 is a critical homeostasis-maintaining factor, particularly following oxidative stress. Although...
38.
Lu W, Hawley B, Skalka G, Baldock R, Smith E, Bader A, et al.
Nat Commun
. 2018 Feb;
9(1):532.
PMID: 29416038
The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of DNA damage but the mechanism remains...
39.
Chernova T, Murphy F, Galavotti S, Sun X, Powley I, Grosso S, et al.
Curr Biol
. 2017 Nov;
27(21):3302-3314.e6.
PMID: 29112861
Mesothelioma is a fatal tumor of the pleura and is strongly associated with asbestos exposure. The molecular mechanisms underlying the long latency period of mesothelioma and driving carcinogenesis are unknown....
40.
Hawley B, Lu W, Wilczynska A, Bushell M
Cell Death Differ
. 2017 Sep;
24(11):1989.
PMID: 28862702
This corrects the article DOI: 10.1038/cdd.2017.16.