Marthe H R Ludtmann
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Explore the profile of Marthe H R Ludtmann including associated specialties, affiliations and a list of published articles.
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17
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1194
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Recent Articles
1.
Soutar M, Kempthorne L, Annuario E, Luft C, Wray S, Ketteler R, et al.
Autophagy
. 2019 May;
15(11):2002-2011.
PMID: 31060423
Mitochondrial quality control is essential for maintaining a healthy population of mitochondria. Two proteins associated with Parkinson disease, the kinase PINK1 and the E3 ubiquitin ligase PRKN, play a central...
2.
Ludtmann M, Kostic M, Horne A, Gandhi S, Sekler I, Abramov A
Cell Death Dis
. 2019 Mar;
10(4):265.
PMID: 30890692
Variants of leucine-rich repeat kinase 2 (lrrk2) are associated with an increased risk in developing Parkinson's disease (PD). Mitochondrial dysfunction and specifically mitochondrial Ca handling has been linked to the...
3.
Ludtmann M, Angelova P, Horrocks M, Choi M, Rodrigues M, Baev A, et al.
Nat Commun
. 2018 Jun;
9(1):2293.
PMID: 29895861
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that...
4.
Manole A, Jaunmuktane Z, Hargreaves I, Ludtmann M, Salpietro V, Bello O, et al.
Brain
. 2017 Oct;
140(11):2820-2837.
PMID: 29053833
Brown-Vialetto-Van Laere syndrome represents a phenotypic spectrum of motor, sensory, and cranial nerve neuropathy, often with ataxia, optic atrophy and respiratory problems leading to ventilator-dependence. Loss-of-function mutations in two riboflavin...
5.
Ludtmann M, Abramov A
Neurosci Lett
. 2017 Aug;
663:86-90.
PMID: 28838811
Multiple factors are involved in the mechanism(s) of neuronal loss in neurodegenerative disorders whilst mitochondria are thought to play a central role in neurodegeneration of Parkinson's disease. Mitochondria are vital...
6.
Ludtmann M, Arber C, Bartolome F, de Vicente M, Preza E, Carro E, et al.
J Biol Chem
. 2017 Apr;
292(21):8907-8917.
PMID: 28360103
Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived mutant fibroblasts exhibit lower mitochondrial membrane potential, uncoupled respiration,...
7.
Ludtmann M, Angelova P, Ninkina N, Gandhi S, Buchman V, Abramov A
J Neurosci
. 2016 Oct;
36(41):10510-10521.
PMID: 27733604
Significance Statement: Misfolded α-synuclein aggregations in the form of Lewy bodies have been shown to be a pathological hallmark in histological staining of Parkinson's disease (PD) patient brains. It is...
8.
Angelova P, Ludtmann M, Horrocks M, Negoda A, Cremades N, Klenerman D, et al.
J Cell Sci
. 2016 Mar;
129(9):1792-801.
PMID: 26989132
Aggregation of α-synuclein leads to the formation of oligomeric intermediates that can interact with membranes to form pores. However, it is unknown how this leads to cell toxicity in Parkinson's...
9.
Deas E, Cremades N, Angelova P, Ludtmann M, Yao Z, Chen S, et al.
Antioxid Redox Signal
. 2015 Nov;
24(7):376-91.
PMID: 26564470
Aims: Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In...
10.
Kostic M, Ludtmann M, Bading H, Hershfinkel M, Steer E, Chu C, et al.
Cell Rep
. 2015 Oct;
13(2):376-86.
PMID: 26440884
Mitochondrial Ca(2+) overload is a critical, preceding event in neuronal damage encountered during neurodegenerative and ischemic insults. We found that loss of PTEN-induced putative kinase 1 (PINK1) function, implicated in...