Marta Than
Overview
Explore the profile of Marta Than including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
101
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Recent Articles
1.
Baska F, Bozo E, Szeleczky Z, Szanto G, Vukics K, Szakacs Z, et al.
J Med Chem
. 2024 Jan;
67(1):643-673.
PMID: 38165765
The V1a receptor is a major contributor in mediating the social and emotional effects of arginine-vasopressin (AVP); therefore it represents a promising target in the treatment of several neuropsychiatric conditions....
2.
Ledneczki I, Nemethy Z, Molnar K, Tapolcsanyi P, Ilkei V, Vago I, et al.
J Med Chem
. 2023 Nov;
66(23):16276-16302.
PMID: 37989278
During optimization of a previously identified lead compound, attempts were made to optimize the reactive indole structural element, the suboptimal metabolic stability, as well as the low kinetic solubility. It...
3.
Szabo G, Elias O, Erdelyi P, Potor A, Turos G, Karolyi B, et al.
J Med Chem
. 2022 May;
65(11):7876-7895.
PMID: 35584373
The discovery and characterization of novel naphthyridine derivatives with selective α5-GABAR negative allosteric modulator (NAM) activity are disclosed. Utilizing a scaffold-hopping strategy, fused [6 + 6] bicyclic scaffolds were designed...
4.
Ledneczki I, Horvath A, Tapolcsanyi P, Eles J, Molnar K, Vago I, et al.
Eur J Med Chem
. 2021 Jun;
222:113560.
PMID: 34111828
HTS campaign of the corporate compound collection resulted in a novel, oxalic acid diamide scaffold of α7 nACh receptor positive allosteric modulators. During the hit expansion, several derivatives, such as...
5.
Ledneczki I, Tapolcsanyi P, Gabor E, Visegrady A, Vass M, Eles J, et al.
Eur J Med Chem
. 2021 Feb;
214:113189.
PMID: 33540354
The paper focuses on the scaffold hopping-based discovery and characterization of novel nicotinic alpha 7 receptor positive modulator (α7 nAChR PAM) ligands around the reference molecule (A-867744). First, substantial efforts...
6.
Than M, Kocsis P, Tihanyi K, Fodor L, Farkas B, Kovacs G, et al.
Neurochem Int
. 2007 Feb;
50(4):642-52.
PMID: 17280740
Chronic pain states and epilepsies are common therapeutic targets of voltage-gated sodium channel blockers. Inhibition of sodium channels results in central muscle relaxant activity as well. Selective serotonin reuptake inhibitors...
7.
Kocsis P, Farkas S, Fodor L, Bielik N, Than M, Kolok S, et al.
J Pharmacol Exp Ther
. 2005 Aug;
315(3):1237-46.
PMID: 16126840
The spinal reflex depressant mechanism of tolperisone and some of its structural analogs with central muscle relaxant action was investigated. Tolperisone (50-400 microM), eperisone, lanperisone, inaperisone, and silperisone (25-200 microM)...
8.
Szabo B, Than M, Thorn D, Wallmichrath I
J Pharmacol Exp Ther
. 2004 May;
310(3):915-25.
PMID: 15123767
The hypothesis of the present work was that activation of CB1 cannabinoid receptors inhibits GABAergic neurotransmission between basket and Purkinje cells in the cerebellar cortex. The aim was to test...
9.
Helyes Z, Nemeth J, Than M, Bolcskei K, Pinter E, Szolcsanyi J
Life Sci
. 2003 Aug;
73(18):2345-53.
PMID: 12941436
Anandamide (AEA) is an endogenous cannabinoid ligand acting predominantly on the cannabinoid 1 (CB(1)) receptor, but it is also an agonist on the capsaicin VR(1)/TRPV(1) receptor. In the present study...
10.
Nemeth J, Helyes Z, Than M, Jakab B, Pinter E, Szolcsanyi J
Neurosci Lett
. 2002 Dec;
336(2):89-92.
PMID: 12499047
Most actions of anandamide (AEA) are mediated by the cannabinoid 1 (CB(1)) receptor activation, but on sensory neurones it is also an agonist on the vanilloid subtype 1 receptor (VR(1))....