Marloes A H M Michels
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Explore the profile of Marloes A H M Michels including associated specialties, affiliations and a list of published articles.
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11
Citations
62
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Recent Articles
1.
Engelke U, Zammit A, Gerritsen A, Michels M, Coene K, Kluijtmans L, et al.
Methods Mol Biol
. 2024 Oct;
2855:555-571.
PMID: 39354327
Inborn errors of metabolism constitute a set of hereditary diseases that impose severe medical and physical challenges in the affected individual, in particular, for the pediatric patient population. Timely diagnosis...
2.
Stevens K, Baas L, van der Velden T, Bouwmeester R, van Dillen N, Dorresteijn E, et al.
Front Immunol
. 2023 Nov;
14:1206409.
PMID: 37954621
Introduction: Atypical hemolytic uremic syndrome (aHUS) is a rare kidney disease caused by dysregulation of the complement alternative pathway. The complement dysregulation specifically leads to damage to the glomerular endothelium....
3.
Michels M, Volokhina E, van de Kar N, van den Heuvel L
Front Immunol
. 2022 Dec;
13:1036136.
PMID: 36451820
Nephritic factors (NeFs) are autoantibodies promoting the activity of the central enzymes of the complement cascade, an important first line of defense of our innate immune system. NeFs stabilize the...
4.
Brandwijk R, Michels M, van Rossum M, de Nooijer A, Nilsson P, de Bruin W, et al.
Front Immunol
. 2022 Nov;
13:1007102.
PMID: 36330514
Background: The complement system is an essential component of our innate defense and plays a vital role in the pathogenesis of many diseases. Assessment of complement activation is critical in...
5.
Michels M, Maas R, van der Velden T, van de Kar N, van den Heuvel L, Volokhina E
J Immunol
. 2021 Oct;
207(10):2465-2472.
PMID: 34635587
The complement system is an important part of innate immunity. Complement activation leads to formation of convertase enzymes, switch of their specificity from C3 to C5 cleavage, and generation of...
6.
Michels M, Wijnsma K, Kurvers R, Westra D, Schreuder M, van Wijk J, et al.
Pediatr Nephrol
. 2021 Sep;
37(3):601-612.
PMID: 34476601
Background: C3 glomerulopathy (C3G) is a rare kidney disorder characterized by predominant glomerular depositions of complement C3. C3G can be subdivided into dense deposit disease (DDD) and C3 glomerulonephritis (C3GN)....
7.
Michels M, van de Kar N, van Kraaij S, Sarlea S, Gracchi V, Engels F, et al.
Front Immunol
. 2021 Aug;
12:715704.
PMID: 34456924
The rare and heterogeneous kidney disorder C3 glomerulopathy (C3G) is characterized by dysregulation of the alternative pathway (AP) of the complement system. C3G is often associated with autoantibodies stabilizing the...
8.
Michels M, van de Kar N, Volokhina E, van den Heuvel B
Methods Mol Biol
. 2021 Apr;
2227:83-96.
PMID: 33847933
The complement system is a key part of innate immunity. However, if the system becomes dysregulated, damage to healthy host cells can occur, especially to the glomerular cells of the...
9.
Michels M, van de Kar N, van den Bos R, van der Velden T, van Kraaij S, Sarlea S, et al.
Front Immunol
. 2019 Jul;
10:1350.
PMID: 31263464
C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of...
10.
Michels M, Volokhina E, van de Kar N, van den Heuvel L
Pediatr Nephrol
. 2018 Aug;
34(8):1349-1367.
PMID: 30141176
Properdin is known as the only positive regulator of the complement system. Properdin promotes the activity of this defense system by stabilizing its key enzymatic complexes: the complement alternative pathway...