Marlene Huyvaert
Overview
Explore the profile of Marlene Huyvaert including associated specialties, affiliations and a list of published articles.
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9
Citations
355
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Recent Articles
1.
Meulebrouck S, Merrheim J, Queniat G, Bourouh C, Derhourhi M, Boissel M, et al.
Nat Commun
. 2024 Aug;
15(1):6627.
PMID: 39103322
Functional genetics has identified drug targets for metabolic disorders. Opioid use impacts metabolic homeostasis, although mechanisms remain elusive. Here, we explore the OPRD1 gene (encoding delta opioid receptor, DOP) to...
2.
Baron M, Maillet J, Huyvaert M, Dechaume A, Boutry R, Loiselle H, et al.
Nat Med
. 2019 Nov;
25(11):1733-1738.
PMID: 31700171
The G-protein-coupled receptor accessory protein MRAP2 is implicated in energy control in rodents, notably via the melanocortin-4 receptor. Although some MRAP2 mutations have been described in people with obesity, their...
3.
Ndiaye F, Huyvaert M, Ortalli A, Canouil M, Lecoeur C, Verbanck M, et al.
Int J Obes (Lond)
. 2019 Aug;
44(2):539-543.
PMID: 31388097
Background: Genome-wide association studies (GWAS) have identified more than 250 loci associated with body mass index (BMI) and obesity. However, post-GWAS functional genomic investigations have been inadequate for understanding how...
4.
Ndiaye F, Ortalli A, Canouil M, Huyvaert M, Salazar-Cardozo C, Lecoeur C, et al.
Mol Metab
. 2017 Jun;
6(6):459-470.
PMID: 28580277
Objectives: Genome-wide association studies (GWAS) have identified >100 loci independently contributing to type 2 diabetes (T2D) risk. However, translational implications for precision medicine and for the development of novel treatments...
5.
Mejia-Benitez M, Bonnefond A, Yengo L, Huyvaert M, Dechaume A, Peralta-Romero J, et al.
Diabetologia
. 2014 Nov;
58(2):290-4.
PMID: 25394825
Aims/hypothesis: Childhood obesity is a major public health problem in Mexico, affecting one in every three children. Genome-wide association studies identified genetic variants associated with childhood obesity, but a large...
6.
Falchi M, El-Sayed Moustafa J, Takousis P, Pesce F, Bonnefond A, Andersson-Assarsson J, et al.
Nat Genet
. 2014 Apr;
46(5):492-7.
PMID: 24686848
Common multi-allelic copy number variants (CNVs) appear enriched for phenotypic associations compared to their biallelic counterparts. Here we investigated the influence of gene dosage effects on adiposity through a CNV...
7.
Neve B, le Bacquer O, Caron S, Huyvaert M, Leloire A, Poulain-Godefroy O, et al.
Diabetologia
. 2014 Jan;
57(4):785-96.
PMID: 24463962
Aims/hypothesis: Gene polymorphisms of TCF7L2 are associated with increased risk of type 2 diabetes and transcription factor 7-like 2 (TCF7L2) plays a role in hepatic glucose metabolism. We therefore addressed...
8.
Bonnefond A, Philippe J, Durand E, Dechaume A, Huyvaert M, Montagne L, et al.
PLoS One
. 2012 Jun;
7(6):e37423.
PMID: 22701567
Background: Maturity-onset of the young (MODY) is a clinically heterogeneous form of diabetes characterized by an autosomal-dominant mode of inheritance, an onset before the age of 25 years, and a...
9.
Marquez M, Huyvaert M, Perry J, Pearson R, Falchi M, Morris A, et al.
Diabetes
. 2012 Jan;
61(2):524-30.
PMID: 22210315
It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group A1 (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk. In our study, we...