Marketa Smidkova
Overview
Explore the profile of Marketa Smidkova including associated specialties, affiliations and a list of published articles.
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15
Citations
91
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0
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Recent Articles
1.
Voldrich J, Matousova M, Smidkova M, Mertlikova-Kaiserova H
ChemMedChem
. 2024 Sep;
19(24):e202400383.
PMID: 39221492
Ion channels represent a druggable family of transmembrane pore-forming proteins with important (patho)physiological functions. While electrophysiological measurement (manual patch clamp) remains the only direct method for detection of ion currents,...
2.
Skacel J, Djukic S, Baszczynski O, Kalcic F, Bilek T, Chalupsky K, et al.
J Med Chem
. 2023 May;
66(10):6652-6681.
PMID: 37134237
Purine nucleoside phosphorylase (PNP) is a well-known molecular target with potential therapeutic applications in the treatment of T-cell malignancies and/or bacterial/parasitic infections. Here, we report the design, development of synthetic...
3.
Voldrich J, Matousova M, Smidkova M, Slavikova B, Chodounska H, Kudova E, et al.
Eur J Pharmacol
. 2022 May;
927:175056.
PMID: 35636520
The goal of this study was to evaluate mixed cortical and hippocampal primary rat postnatal neuronal culture as in vitro tool for identification of N-methyl-D-aspartate receptor (NMDAR) antagonists and to...
4.
Prochazkova E, Hrebabecky H, Dejmek M, Sala M, Smidkova M, Tloustova E, et al.
Bioorg Med Chem Lett
. 2019 Dec;
30(4):126897.
PMID: 31882298
The nucleoside/nucleotide derived antiviral agents have been the most important components of antiviral therapy used in clinics. Recently, the focus of the medicinal chemists within this exciting research field has...
5.
Smidkova M, Hajek M, Adla S, Slavikova B, Chodounska H, Matousova M, et al.
J Steroid Biochem Mol Biol
. 2019 Mar;
189:195-203.
PMID: 30872014
A broad variety of central nervous system diseases have been associated with glutamate induced excitotoxicity under pathological conditions. The neuroprotective effects of neurosteroids can combat this excitotoxicity. Herein, we have...
6.
Adla S, Slavikova B, Chodounska H, Vyklicky V, Ladislav M, Hubalkova P, et al.
Front Pharmacol
. 2018 Nov;
9:1299.
PMID: 30483134
Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of -methyl-D-aspartate receptors (NMDARs) receptors that employ an amide structural motif, relative to pregnanolone glutamate (PAG)...
7.
cesnek M, Skacel J, Jansa P, Dracinsky M, Smidkova M, Mertlikova-Kaiserova H, et al.
ChemMedChem
. 2018 Jul;
13(17):1779-1796.
PMID: 29968968
A series of 13 acyclic nucleoside phosphonates (ANPs) as bisamidate prodrugs was prepared. Five compounds were found to be non-cytotoxic and selective inhibitors of Bordetella pertussis adenylate cyclase toxin (ACT)...
8.
Frydrych J, Skacel J, Smidkova M, Mertlikova-Kaiserova H, Dracinsky M, Gnanasekaran R, et al.
ChemMedChem
. 2017 Dec;
13(2):199-206.
PMID: 29235265
Inhibition of Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema factor (EF), key virulence factors with adenylate cyclase activity, represents a potential method for treating or preventing toxemia...
9.
Brehova P, Smidkova M, Skacel J, Dracinsky M, Mertlikova-Kaiserova H, Velasquez M, et al.
ChemMedChem
. 2016 Oct;
11(22):2534-2546.
PMID: 27775243
Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema factor (EF) are key virulence factors with adenylate cyclase (AC) activity that substantially contribute to the pathogenesis of whooping cough...
10.
Adla S, Slavikova B, Smidkova M, Tloustova E, Svoboda M, Vyklicky V, et al.
Steroids
. 2016 Aug;
117:52-61.
PMID: 27544449
Herein, we report a new class of amide-based inhibitors (1-4) of N-methyl-d-aspartate receptors (NMDARs) that were prepared as analogues of pregnanolone sulfate (PAS) and pregnanolone glutamate (PAG) - the steroidal...