Mark W Hankins
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Explore the profile of Mark W Hankins including associated specialties, affiliations and a list of published articles.
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66
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2535
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Recent Articles
1.
Rodgers J, Hughes S, Ebrahimi A, Allen A, Storchi R, Lindner M, et al.
Mol Ther
. 2025 Jan;
33(3):1264-1281.
PMID: 39825567
Optogenetic therapy is a promising vision restoration method where light-sensitive opsins are introduced to the surviving inner retina following photoreceptor degeneration. The cell type targeted for opsin expression will likely...
2.
Rodgers J, Hughes S, Lindner M, Allen A, Ebrahimi A, Storchi R, et al.
Curr Biol
. 2024 Jan;
34(1):224-233.
PMID: 38194917
No abstract available.
3.
Rodgers J, Hughes S, Lindner M, Allen A, Ebrahimi A, Storchi R, et al.
Curr Biol
. 2023 Jan;
33(3):474-486.e5.
PMID: 36630957
Photoreceptor degeneration sufficient to produce severe visual loss often spares the inner retina. This raises hope for vision restoration treatments using optogenetics or electrical stimulation, which generate a replacement light...
4.
Lindner M, Gilhooley M, Hughes S, Hankins M
Prog Retin Eye Res
. 2022 Jun;
91:101089.
PMID: 35691861
Degenerative retinal disorders are a diverse family of diseases commonly leading to irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent years, innovative gene replacement therapies aiming...
5.
Gilhooley M, Lindner M, Palumaa T, Hughes S, Peirson S, Hankins M
Mol Ther Methods Clin Dev
. 2022 Apr;
25:111-123.
PMID: 35402632
During inherited retinal degenerations (IRDs), vision is lost due to photoreceptor cell death; however, a range of optogenetic tools have been shown to restore light responses in animal models. Restored...
6.
Hughes S, Edwards J, Wilcox A, Pothecary C, Barnard A, Joynson R, et al.
FASEB J
. 2021 Aug;
35(9):e21802.
PMID: 34383984
Mutations in transcription factors often exhibit pleiotropic effects related to their complex expression patterns and multiple regulatory targets. One such mutation in the zinc finger homeobox 3 (ZFHX3) transcription factor,...
7.
Hickey D, Davies W, Hughes S, Rodgers J, Thavanesan N, MacLaren R, et al.
J Exp Biol
. 2021 Jun;
224(14).
PMID: 34151984
Human opsin-based photopigments have great potential as light-sensitisers, but their requirement for phototransduction cascade-specific second messenger proteins may restrict their functionality in non-native cell types. In this study, eight chimeric...
8.
Gilhooley M, Hickey D, Lindner M, Palumaa T, Hughes S, Peirson S, et al.
Exp Eye Res
. 2021 Apr;
207:108553.
PMID: 33811915
Purpose: Retinal bipolar cells survive even in the later stages of inherited retinal degenerations (IRDs) and so are attractive targets for optogenetic approaches to vision restoration. However, it is not...
9.
Lindner M, Gilhooley M, Peirson S, Hughes S, Hankins M
Cell Mol Life Sci
. 2020 Jul;
78(4):1597-1613.
PMID: 32728765
Optogenetic strategies to restore vision in patients blind from end-stage retinal degenerations aim to render remaining retinal neurons light-sensitive. We present an innovative combination of multi-electrode array recordings together with ...
10.
Lindner M, Gilhooley M, Palumaa T, Morton A, Hughes S, Hankins M
Invest Ophthalmol Vis Sci
. 2020 Mar;
61(3):33.
PMID: 32191288
Purpose: To characterize the retinal expression and localization of Kcne2, an ancillary (β) ion-channel subunit with an important role in fine-tuning cellular excitability. Methods: We analyzed available single-cell transcriptome data...