Mark van Breugel
Overview
Explore the profile of Mark van Breugel including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
698
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0
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Recent Articles
1.
Carden S, Vitiello E, E Silva I, Holder J, Quarantotti V, Kishore K, et al.
Dev Cell
. 2023 Oct;
58(21):2393-2410.e9.
PMID: 37852252
Centrosomes are the major microtubule-organizing centers in animals and play fundamental roles in many cellular processes. Understanding how their composition varies across diverse cell types and how it is altered...
2.
van Breugel M, E Silva I, Andreeva A
Commun Biol
. 2022 Apr;
5(1):312.
PMID: 35383272
Obtaining the high-resolution structures of proteins and their complexes is a crucial aspect of understanding the mechanisms of life. Experimental structure determination methods are time-consuming, expensive and cannot keep pace...
3.
E Silva I, Bino L, Johnson C, Rutherford T, Neuhaus D, Andreeva A, et al.
Structure
. 2021 Sep;
30(1):114-128.e9.
PMID: 34499853
Cilia formation is essential for human life. One of the earliest events in the ciliogenesis program is the recruitment of tau-tubulin kinase 2 (TTBK2) by the centriole distal appendage component...
4.
Ochi T, Quarantotti V, Lin H, Jullien J, E Silva I, Boselli F, et al.
Structure
. 2020 May;
28(6):674-689.e11.
PMID: 32375023
Centrioles are cylindrical assemblies whose peripheral microtubule array displays a 9-fold rotational symmetry that is established by the scaffolding protein SAS6. Centriole symmetry can be broken by centriole-associated structures, such...
5.
Liu Y, Kim J, Philip R, Sridhar V, Chandrashekhar M, Moffat J, et al.
J Cell Sci
. 2020 Feb;
133(8).
PMID: 32107292
PLK4 has emerged as a prime target for cancer therapeutics, and its overexpression is frequently observed in various types of human cancer. Recent studies have further revealed an unexpected oncogenic...
6.
Joseph N, Al-Jassar C, Johnson C, Andreeva A, Barnabas D, Freund S, et al.
Cell Rep
. 2018 May;
23(9):2805-2818.
PMID: 29847808
Ciliopathies are a group of genetic disorders caused by a failure to form functional cilia. Due to a lack of structural information, it is currently poorly understood how ciliopathic mutations...
7.
Liu Y, Gupta G, Barnabas D, Agircan F, Mehmood S, Wu D, et al.
Nat Commun
. 2018 May;
9(1):1731.
PMID: 29712910
Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the microtubule-nucleating pericentriolar material. Centriole duplication is tightly controlled in...
8.
Al-Jassar C, Andreeva A, Barnabas D, McLaughlin S, Johnson C, Yu M, et al.
Structure
. 2016 Dec;
25(1):146-156.
PMID: 28017521
Cilia are thin cell projections with essential roles in cell motility, fluid movement, sensing, and signaling. They are templated from centrioles that dock against the plasma membrane and subsequently extend...
9.
van Breugel M, Wilcken R, McLaughlin S, Rutherford T, Johnson C
Elife
. 2014 Mar;
3:e01812.
PMID: 24596152
Centrioles are cylindrical cell organelles with a ninefold symmetric peripheral microtubule array that is essential to template cilia and flagella. They are built around a central cartwheel assembly that is...
10.
Cottee M, Muschalik N, Liang Wong Y, Johnson C, Johnson S, Andreeva A, et al.
Elife
. 2013 Sep;
2:e01071.
PMID: 24052813
Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and...