Mark T Keating
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Explore the profile of Mark T Keating including associated specialties, affiliations and a list of published articles.
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43
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5115
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Recent Articles
11.
Schebesta M, Lien C, Engel F, Keating M
ScientificWorldJournal
. 2007 Jan;
6 Suppl 1:38-54.
PMID: 17205186
Regeneration of severed limbs in adult animals is restricted to urodele amphibians. Mammals, including humans, have very limited regenerative capabilities and even with proper treatment, only the tips of our...
12.
Engel F, Hsieh P, Lee R, Keating M
Proc Natl Acad Sci U S A
. 2006 Oct;
103(42):15546-51.
PMID: 17032753
Mammalian cardiomyocytes have limited proliferation potential, and acutely injured mammalian hearts do not regenerate adequately. Instead, injured myocardium develops fibrosis and scarring. Here we show that FGF1/p38 MAP kinase inhibitor...
13.
Tseng A, Engel F, Keating M
Chem Biol
. 2006 Sep;
13(9):957-63.
PMID: 16984885
The maintenance of self-renewal in stem cells appears to be distinct from the induction of proliferation of the terminally differentiated mammalian cardiomyocytes because it is believed that the latter are...
14.
Engel F, Schebesta M, Keating M
J Mol Cell Cardiol
. 2006 Aug;
41(4):601-12.
PMID: 16889791
Heart growth is augmented during early development by cardiomyocyte proliferation. In contrast, heart growth during postnatal life occurs by increasing cell size. Postnatal cardiomyocytes can undergo DNA synthesis, mitosis and...
15.
Lien C, Schebesta M, Makino S, Weber G, Keating M
PLoS Biol
. 2006 Jul;
4(8):e260.
PMID: 16869712
Mammalian hearts cannot regenerate. In contrast, zebrafish hearts regenerate even when up to 20% of the ventricle is amputated. The mechanism of zebrafish heart regeneration is not understood. To systematically...
16.
Splawski I, Yoo D, Stotz S, Cherry A, Clapham D, Keating M
J Biol Chem
. 2006 Jun;
281(31):22085-22091.
PMID: 16754686
Autism spectrum disorders (ASD) are neurodevelopmental conditions characterized by impaired social interaction, communication skills, and restricted and repetitive behavior. The genetic causes for autism are largely unknown. Previous studies implicate...
17.
Bayliss P, Bellavance K, Whitehead G, Abrams J, Aegerter S, Robbins H, et al.
Nat Chem Biol
. 2006 Mar;
2(5):265-73.
PMID: 16565716
We examined the role of angiogenesis and the need for receptor signaling using chemical inhibition of the vascular endothelial growth factor receptor in the adult zebrafish tail fin. Using a...
18.
Whitehead G, Makino S, Lien C, Keating M
Science
. 2005 Dec;
310(5756):1957-60.
PMID: 16373575
Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the...
19.
Stevenson T, Vinarsky V, Atkinson D, Keating M, Odelberg S
Dev Dyn
. 2005 Dec;
235(3):606-16.
PMID: 16372340
Matrix metalloproteinase (MMP) activity is important for newt limb regeneration. In most biological processes that require MMP function, MMP activity is tightly controlled by a variety of mechanisms, including the...
20.
Kiehl T, Nechiporuk A, Figueroa K, Keating M, Huynh D, Pulst S
Biochem Biophys Res Commun
. 2005 Nov;
339(1):17-24.
PMID: 16293225
Ataxin-2, the gene product of the Spinocerebellar Ataxia Type 2 (SCA2) gene, is a protein of unknown function with abundant expression in embryonic and adult tissues. Its interaction with A2BP1/Fox-1,...