Mark T Hughes
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Explore the profile of Mark T Hughes including associated specialties, affiliations and a list of published articles.
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49
Citations
684
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Recent Articles
11.
Chen B, Kern D, Kearns R, Thomas P, Hughes M, Tackett S
Acad Med
. 2019 Jan;
94(5):678-685.
PMID: 30681454
Online curricula can make high-quality health professions education accessible in virtually any setting. They can enhance teaching and learning by both standardizing curricular resources and individualizing curricular experiences. Despite growing...
12.
Floros K, Lochmann T, Hu B, Monterrubio C, Hughes M, Wells J, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(11):E2594-E2603.
PMID: 29476008
() amplification is a driving oncogenic event in breast cancer. Clinical trials have consistently shown the benefit of HER2 inhibitors (HER2i) in treating patients with both local and advanced HER2+...
13.
Song K, Niederst M, Lochmann T, Hata A, Kitai H, Ham J, et al.
Clin Cancer Res
. 2017 Oct;
24(1):197-208.
PMID: 29051323
Epithelial-to-mesenchymal transition (EMT) confers resistance to a number of targeted therapies and chemotherapies. However, it has been unclear why EMT promotes resistance, thereby impairing progress to overcome it. We have...
14.
15.
Sulmasy D, Hughes M, Yenokyan G, Kub J, Terry P, Astrow A, et al.
J Pain Symptom Manage
. 2017 Jul;
54(4):455-465.
PMID: 28712987
Context: Patients with terminal illnesses often require surrogate decision makers. Prior research has demonstrated high surrogate stress, and that despite standards promoting substituted judgment, most patients do not want their...
16.
Ferrell B, Paterson C, Hughes M, Chung V, Koczywas M, Smith T
J Palliat Med
. 2017 Jun;
20(12):1338-1344.
PMID: 28609257
Introduction: Advanced cancer patients participating in phase 1 clinical trials experience considerable symptom burden. Palliative care (PC) may benefit these individuals by providing supportive care during clinical research participation. This...
17.
Ho G, Skaggs L, Yenokyan G, Kellogg A, Johnson J, Lee M, et al.
Palliat Support Care
. 2016 May;
15(1):12-19.
PMID: 27237410
Objective: There is a growing body of literature describing the characteristics of patients who plan for the end of life, but little research has examined how caregivers influence patients' advance...
18.
Lee M, Sulmasy D, Gallo J, Kub J, Hughes M, Russell S, et al.
Am J Hosp Palliat Care
. 2016 Apr;
34(6):518-523.
PMID: 27034436
Introduction: Many patients with advanced heart failure (HF) experience the life-extending benefits of implantable cardioverter-defibrillators (ICD), but at the end stage of HF, patients may experience shocks with increasing frequency...
19.
Ham J, Costa C, Sano R, Lochmann T, Sennott E, Patel N, et al.
Cancer Cell
. 2016 Feb;
29(2):159-72.
PMID: 26859456
Fewer than half of children with high-risk neuroblastoma survive. Many of these tumors harbor high-level amplification of MYCN, which correlates with poor disease outcome. Using data from our large drug...
20.
Xu J, Nolan M, Heinze K, Yenokyan G, Hughes M, Johnson J, et al.
Appl Nurs Res
. 2015 Nov;
28(4):311-5.
PMID: 26608431
Purpose: National reports on end-of-life symptom management reveal a gap in the evidence regarding symptoms other than pain and studies of diseases other than cancer. This study examines the frequency...