Mark S Moehle
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Explore the profile of Mark S Moehle including associated specialties, affiliations and a list of published articles.
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26
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1111
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Recent Articles
1.
Chambers N, Hall D, Barsoum S, Miller E, Curry T, Kaplan M, et al.
bioRxiv
. 2024 Sep;
PMID: 39253490
Loss-of-function mutations in have been linked to an adult-onset, isolated dystonia that is largely indistinguishable from idiopathic dystonia. encodes Gα , a heterotrimeric G-protein α subunit with a defined molecular...
2.
Millett M, Heuberger A, Martin Castosa E, Comite A, Wagner P, Hall D, et al.
Brain Res
. 2024 Jul;
1842:149105.
PMID: 38960060
The heterotrimeric G-protein α subunit, Gα, acts to transduce extracellular signals through G-protein coupled receptors (GPCRs) and stimulates adenylyl cyclase mediated production of the second messenger cyclic adenosine monophosphate. Numerous...
3.
LeWitt P, Hong L, Moehle M
J Neural Transm (Vienna)
. 2024 Jun;
131(12):1481-1494.
PMID: 38904792
Anticholinergic (AC) drugs, a medication class that acts by blocking nicotinic and muscarinic acetylcholine receptors, were first utilized for therapeutic purposes in the mid-19th century. Initial applications were as symptomatic...
4.
Millett M, Heuberger A, Martin Castosa E, Comite A, Wagner P, Hall D, et al.
bioRxiv
. 2024 Apr;
PMID: 38617339
The heterotrimeric G-protein α subunit, Gα , acts to transduce extracellular signals through G-protein coupled receptors (GPCRs) and stimulates adenylyl cyclase mediated production of the second messenger cyclic adenosine monophosphate....
5.
Bu M, Follett J, Deng I, Tatarnikov I, Wall S, Guenther D, et al.
NPJ Parkinsons Dis
. 2023 Dec;
9(1):167.
PMID: 38110354
Dysregulation of dopamine neurotransmission profoundly affects motor, motivation and learning behaviors, and can be observed during the prodromal phase of Parkinson's disease (PD). However, the mechanism underlying these pathophysiological changes...
6.
Qi A, Kling H, Billard N, Rodriguez A, Peng L, Dickerson J, et al.
Mol Pharmacol
. 2023 Aug;
104(5):195-202.
PMID: 37595966
M muscarinic receptors are highly expressed in the striatum and cortex, brain regions that are involved in diseases such as Parkinson's disease, schizophrenia, and dystonia. Despite potential therapeutic advantages of...
7.
Chambers N, Millett M, Moehle M
Biochem Soc Trans
. 2023 Apr;
51(2):691-702.
PMID: 37013974
Barbeau's seesaw hypothesis of dopamine-acetylcholine balance has predominated movement disorders literature for years. Both the simplicity of the explanation and the matching efficacy of anticholinergic treatment in movement disorders seem...
8.
Bohnen N, Yarnall A, Weil R, Moro E, Moehle M, Borghammer P, et al.
Lancet Neurol
. 2022 Feb;
21(4):381-392.
PMID: 35131038
In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur in different brain regions. These changes correlate with a range of clinical features, both motor and non-motor, that are...
9.
Abdelmotilib H, Maltbie T, Delic V, Liu Z, Hu X, Fraser K, et al.
Neurobiol Dis
. 2021 Sep;
159:105506.
PMID: 34565675
No abstract available.
10.
Moehle M, Bender A, Dickerson J, Foster D, Qi A, Cho H, et al.
ACS Pharmacol Transl Sci
. 2021 Aug;
4(4):1306-1321.
PMID: 34423268
Nonselective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson's disease and dystonia. Despite their efficacy...