Mark Rose
Overview
Explore the profile of Mark Rose including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
678
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Recent Articles
1.
Muntasser S, Bridle K, Ellison M, Darveaux B, Rose M, Stuart W
Explore (NY)
. 2023 Apr;
19(3):483-486.
PMID: 37030978
No abstract available.
2.
Ladduwahetty T, Lee M, Maillard M, Cachope R, Todd D, Barnes M, et al.
J Med Chem
. 2022 Jul;
65(14):9819-9845.
PMID: 35816678
The Rho kinase (ROCK) pathway is implicated in the pathogenesis of several conditions, including neurological diseases. In Huntington's disease (HD), ROCK is implicated in mutant huntingtin (HTT) aggregation and neurotoxicity,...
3.
Fernandez-Metzler C, Ackermann B, Garofolo F, Arnold M, DeSilva B, Gu H, et al.
AAPS J
. 2022 May;
24(3):66.
PMID: 35534647
Decades of discussion and publication have gone into the guidance from the scientific community and the regulatory agencies on the use and validation of pharmacokinetic and toxicokinetic assays by chromatographic...
4.
Van de Poel A, Toledo-Sherman L, Breccia P, Cachope R, Bate J, Angulo-Herrera I, et al.
J Med Chem
. 2021 Mar;
64(8):5018-5036.
PMID: 33783225
Our group has recently shown that brain-penetrant ataxia telangiectasia-mutated (ATM) kinase inhibitors may have potential as novel therapeutics for the treatment of Huntington's disease (HD). However, the previously described pyranone-thioxanthenes...
5.
Gilliam W, Barr J, Bruns B, Cave B, Mitchell J, Nguyen T, et al.
World J Emerg Med
. 2021 Jan;
12(1):12-17.
PMID: 33505544
Background: Oligoanalgesia in emergency departments (EDs) is multifactorial. A previous study reported that emergency providers did not adequately manage patients with severe pain despite objective findings for surgical pathologies. Our...
6.
Tran Q, Walker A, Berman E, Vesselinov R, Rose M, Tiffany L, et al.
J Emerg Trauma Shock
. 2020 Dec;
13(3):234-235.
PMID: 33304079
No abstract available.
7.
Di Marco A, Vignone D, Paz O, Fini I, Battista M, Cellucci A, et al.
Cells
. 2020 Apr;
9(4).
PMID: 32316221
The blood-brain barrier (BBB) is responsible for the homeostasis between the cerebral vasculature and the brain and it has a key role in regulating the influx and efflux of substances,...
8.
Rose M, Newton C, Boualam B, Hassan M, Bogne N, Mitchell J, et al.
Air Med J
. 2019 May;
38(3):188-194.
PMID: 31122585
Introduction: Patients with acute aortic diseases (AAoD) usually require transfer to tertiary centers for possible surgical care, for which intratransport management represents important continuing spectrum of care. There is little...
9.
Di Marco A, Paz O, Fini I, Vignone D, Cellucci A, Battista M, et al.
Mol Pharm
. 2019 Mar;
16(5):2069-2082.
PMID: 30916978
Huntington's disease (HD) is a neurodegenerative disease caused by polyglutamine expansion in the huntingtin protein. For drug candidates targeting HD, the ability to cross the blood-brain barrier (BBB) and reach...
10.
Toledo-Sherman L, Breccia P, Cachope R, Bate J, Angulo-Herrera I, Wishart G, et al.
J Med Chem
. 2019 Mar;
62(6):2988-3008.
PMID: 30840447
Genetic and pharmacological evidence indicates that the reduction of ataxia telangiectasia-mutated (ATM) kinase activity can ameliorate mutant huntingtin (mHTT) toxicity in cellular and animal models of Huntington's disease (HD), suggesting...