Mark R Mizee
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Explore the profile of Mark R Mizee including associated specialties, affiliations and a list of published articles.
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14
Citations
999
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Recent Articles
1.
Bink D, Bink D, Ritz K, Mackaaij C, Stam O, Scheffer S, et al.
Vasc Biol
. 2025 Jan;
7(1).
PMID: 39812587
Although mice are used extensively to study atherosclerosis of different vascular beds, limited data are published on the occurrence of intracranial atherosclerosis. Since intracranial atherosclerosis is a common cause of...
2.
Scheepstra K, Mizee M, van Scheppingen J, Adelia A, Wever D, Mason M, et al.
Biol Psychiatry
. 2023 Apr;
94(8):619-629.
PMID: 37121366
Background: Microglia have been implicated in the pathophysiology of major depressive disorder (MDD), but information on biological mechanisms is limited. Therefore, we investigated the gene expression profile of microglial cells...
3.
Henneman P, Mul A, Li Yim A, Krzyzewska I, Alders M, Adelia A, et al.
Epigenomics
. 2022 Mar;
14(7):375-390.
PMID: 35232286
To detect expression quantitative trait methylation (eQTM) loci within the cerebrum of prenatal Down syndrome (DS) and controls. DNA methylation gene expression profiles were acquired from NeuN+ nuclei, obtained from...
4.
Bottcher C, van der Poel M, Fernandez-Zapata C, Schlickeiser S, Leman J, Hsiao C, et al.
Acta Neuropathol Commun
. 2020 Aug;
8(1):136.
PMID: 32811567
Myeloid cells contribute to inflammation and demyelination in the early stages of multiple sclerosis (MS), but it is still unclear to what extent these cells are involved in active lesion...
5.
Fransen N, Crusius J, Smolders J, Mizee M, van Eden C, Luchetti S, et al.
Brain Pathol
. 2019 Jun;
30(1):106-119.
PMID: 31228212
Over the last few decades, several common single nucleotide polymorphisms (SNPs) have been identified that correlate with clinical outcome in multiple sclerosis (MS), but the pathogenic mechanisms underlying the clinical...
6.
van der Poel M, Ulas T, Mizee M, Hsiao C, Miedema S, Adelia , et al.
Nat Commun
. 2019 Mar;
10(1):1139.
PMID: 30867424
Here we report the transcriptional profile of human microglia, isolated from normal-appearing grey matter (GM) and white matter (WM) of multiple sclerosis (MS) and non-neurological control donors, to find possible...
7.
Mizee M, Miedema S, van der Poel M, Adelia , Schuurman K, van Strien M, et al.
Acta Neuropathol Commun
. 2017 Feb;
5(1):16.
PMID: 28212663
Microglia are key players in the central nervous system in health and disease. Much pioneering research on microglia function has been carried out in vivo with the use of genetic...
8.
Lopes Pinheiro M, Kooij G, Mizee M, Kamermans A, Enzmann G, Lyck R, et al.
Biochim Biophys Acta
. 2015 Nov;
1862(3):461-71.
PMID: 26527183
Each year about 650,000 Europeans die from stroke and a similar number lives with the sequelae of multiple sclerosis (MS). Stroke and MS differ in their etiology. Although cause and...
9.
Broux B, Mizee M, Vanheusden M, van der Pol S, van Horssen J, Van Wijmeersch B, et al.
J Immunol
. 2015 Jan;
194(5):2099-109.
PMID: 25617471
CD4(+)CD28(-) T cells arise through repeated antigenic stimulation and are present in diseased tissues of patients with various autoimmune disorders, including multiple sclerosis (MS). These cells are believed to have...
10.
Mizee M, Nijland P, van der Pol S, Drexhage J, van Het Hof B, Mebius R, et al.
Acta Neuropathol
. 2014 Aug;
128(5):691-703.
PMID: 25149081
Multiple sclerosis (MS) lesions are characterized by the presence of activated astrocytes, which are thought to actively take part in propagating lesion progression by secreting pro-inflammatory mediators. Conversely, reactive astrocytes...