Mark R Boothby
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Explore the profile of Mark R Boothby including associated specialties, affiliations and a list of published articles.
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37
Citations
1555
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Recent Articles
1.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik J, Chen Y, et al.
Nat Commun
. 2024 Nov;
15(1):10163.
PMID: 39580479
Germinal center (GC) formation, which is an integrant part of humoral immunity, involves energy-consuming metabolic reprogramming. Rag-GTPases are known to signal amino acid availability to cellular pathways that regulate nutrient...
2.
Cho S, Jones M, Meyer K, Anderson D, Chetyrkin S, Calcutt M, et al.
bioRxiv
. 2024 Oct;
PMID: 39464149
The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate...
3.
Edwards D, Wang S, Song W, Kim L, Ngwa V, Hwang Y, et al.
bioRxiv
. 2024 Apr;
PMID: 38617241
Tumor metastasis, the main cause of death in cancer patients, requires outgrowth of tumor cells after their dissemination and residence in microscopic niches. Nutrient sufficiency is a determinant of such...
4.
Sturniolo I, Varoczy C, Regdon Z, Mazlo A, Muzsai S, Bacsi A, et al.
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612413
Cancers reprogram macrophages (MΦs) to a tumor-growth-promoting TAM (tumor-associated MΦ) phenotype that is similar to the anti-inflammatory M2 phenotype. Poly(ADP-ribose) polymerase (PARP) enzymes regulate various aspects of MΦ biology, but...
5.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik J, Chen Y, et al.
Res Sq
. 2024 Apr;
PMID: 38585731
During the humoral immune response, B cells undergo rapid metabolic reprogramming with a high demand for nutrients, which are vital to sustain the formation of the germinal centers (GCs). Rag-GTPases...
6.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik J, Chen Y, et al.
bioRxiv
. 2024 Mar;
PMID: 38463988
During the humoral immune response, B cells undergo rapid metabolic reprogramming with a high demand for nutrients, which are vital to sustain the formation of the germinal centers (GCs). Rag-GTPases...
7.
Brookens S, Cho S, Paik Y, Meyer K, Raybuck A, Park C, et al.
J Immunol
. 2023 Nov;
212(1):43-56.
PMID: 37955416
Serum Ab concentrations, selection for higher affinity BCRs, and generation of higher Ab affinities are important elements of immune response optimization and functions of germinal center (GC) reactions. B cell...
8.
Brookens S, Cho S, Paik Y, Meyer K, Raybuck A, Park C, et al.
bioRxiv
. 2023 Sep;
PMID: 37745429
Key Points: Glucose influx is critical for GC homeostasis, affinity maturation and the generation of Ab-secreting cells.Plasma cell development uses the Pentose Phosphate Pathway, and hexose sugars maintain redox homeostasis.PCs...
9.
Eddie A, Chen K, Schenkel L, Swinger K, Molina J, Kunii K, et al.
Immunohorizons
. 2022 Jul;
6(7):432-446.
PMID: 35817532
The type 2 cytokines IL-4 and IL-13, which share use of an IL-4 receptor α-chain and its nuclear induction of the transcription factor STAT6, are crucial in elicitation and maintenance...
10.
Xu Z, Boothby M, Chaudhuri J
Front Immunol
. 2021 Dec;
12:797548.
PMID: 34858441
No abstract available.