Mark Noviski
Overview
Explore the profile of Mark Noviski including associated specialties, affiliations and a list of published articles.
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10
Citations
203
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Recent Articles
1.
Montoya S, Bourcier J, Noviski M, Lu H, Thompson M, Chirino A, et al.
Science
. 2024 Feb;
383(6682):eadi5798.
PMID: 38301010
Increasing use of covalent and noncovalent inhibitors of Bruton's tyrosine kinase (BTK) has elucidated a series of acquired drug-resistant BTK mutations in patients with B cell malignancies. Here we identify...
2.
Zhang D, Harris H, Chen J, Judy J, James G, Kelly A, et al.
Blood
. 2022 Nov;
141(13):1584-1596.
PMID: 36375120
Bruton tyrosine kinase (BTK) is essential for B-cell receptor (BCR) signaling, a driver of chronic lymphocytic leukemia (CLL). Covalent inhibitors bind C481 in the active site of BTK and have...
3.
Tan C, Hiwa R, Mueller J, Vykunta V, Hibiya K, Noviski M, et al.
Nat Immunol
. 2020 Sep;
21(10):1267-1279.
PMID: 32868928
Antigen stimulation (signal 1) triggers B cell proliferation and primes B cells to recruit, engage and respond to T cell help (signal 2). Failure to receive signal 2 within a...
4.
Tan C, Noviski M, Huizar J, Zikherman J
Immunol Rev
. 2019 Oct;
292(1):37-60.
PMID: 31631352
Efficient mechanisms of central tolerance, including receptor editing and deletion, prevent highly self-reactive B cell receptors (BCRs) from populating the periphery. Despite this, modest self-reactivity persists in (and may even...
5.
Noviski M, Tan C, Huizar J, Vykunta V, Mueller J, Zikherman J
J Immunol
. 2019 Jun;
203(2):418-428.
PMID: 31167773
It has long been appreciated that highly autoreactive BCRs are actively removed from the developing B cell repertoire by Ag-dependent receptor editing and deletion. However, there is persistent debate about...
6.
Tan C, Mueller J, Noviski M, Huizar J, Lau D, Dubinin A, et al.
J Immunol
. 2019 Apr;
202(10):2907-2923.
PMID: 30962292
Nur77 ( belongs to a small family of orphan nuclear receptors that are rapidly induced by BCR stimulation, yet little is known about its function in B cells. We have...
7.
Noviski M, Zikherman J
Curr Opin Immunol
. 2018 Oct;
55:67-74.
PMID: 30292928
A substantial fraction of mature naïve B cells recognize endogenous antigens, and this autoreactivity must be controlled to prevent autoantibody secretion. Selective downregulation of the IgM BCR on autoreactive B...
8.
Noviski M, Mueller J, Satterthwaite A, Garrett-Sinha L, Brombacher F, Zikherman J
Elife
. 2018 Mar;
7.
PMID: 29521626
Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B cells. Because these...
9.
Huizar J, Tan C, Noviski M, Mueller J, Zikherman J
Immunohorizons
. 2017 Nov;
1(9):188-197.
PMID: 29152611
B-1a cells are a unique population of innate-like B cells with a highly restricted and self-reactive BCR repertoire. Preimmune "natural" IgM produced by B-1a-derived plasma cells is essential for homeostatic...
10.
Coughlin S, Noviski M, Mueller J, Chuwonpad A, Raschke W, Weiss A, et al.
Proc Natl Acad Sci U S A
. 2015 Nov;
112(47):E6515-24.
PMID: 26561584
The receptor-like tyrosine phosphatase CD45 regulates antigen receptor signaling by dephosphorylating the C-terminal inhibitory tyrosine of the src family kinases. However, despite its abundance, the function of the large, alternatively...