James L Mueller
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Explore the profile of James L Mueller including associated specialties, affiliations and a list of published articles.
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43
Citations
2315
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Recent Articles
1.
Nielsen H, Yang L, Mueller J, Ritter A, Hiwa R, Proekt I, et al.
Nat Commun
. 2025 Jan;
16(1):784.
PMID: 39824797
The Nr4a nuclear hormone receptors are transcriptionally upregulated in response to antigen recognition by the T cell receptor (TCR) in the thymus and are implicated in clonal deletion, but the...
2.
Wholey W, Meyer A, Yoda S, Mueller J, Mathenge R, Chackerian B, et al.
J Immunol
. 2024 Aug;
213(8):1061-1075.
PMID: 39212443
Class-switched neutralizing Ab (nAb) production is rapidly induced upon many viral infections. However, due to the presence of multiple components in virions, the precise biochemical and biophysical signals from viral...
3.
Wholey W, Meyer A, Yoda S, Mueller J, Mathenge R, Chackerian B, et al.
bioRxiv
. 2024 Mar;
PMID: 38469153
One-sentence Summary: Reconstitution of minimal viral signals necessary to initiate antiviral IgG.
4.
Brooks J, Riggs J, Mueller J, Mathenge R, Wholey W, Meyer A, et al.
Nat Immunol
. 2023 Aug;
24(10):1762-1777.
PMID: 37653247
Multivalent viral epitopes induce rapid, robust and T cell-independent humoral immune responses, but the biochemical basis for such potency remains incompletely understood. We take advantage of a set of liposomes...
5.
Brooks J, Riggs J, Mueller J, Mathenge R, Wholey W, Yoda S, et al.
bioRxiv
. 2023 Feb;
PMID: 36824873
Although it has long been appreciated that multivalent antigens - and particularly viral epitope display - produce extremely rapid, robust, and T-independent humoral immune responses, the biochemical basis for such...
6.
Hiwa R, Brooks J, Mueller J, Nielsen H, Zikherman J
Immunol Rev
. 2022 Feb;
307(1):116-133.
PMID: 35174510
Random VDJ recombination early in T and B cell development enables the adaptive immune system to recognize a vast array of evolving pathogens via antigen receptors. However, the potential of...
7.
Feldman H, Ghosh R, Auyeung V, Mueller J, Kim J, Potter Z, et al.
Nat Chem Biol
. 2021 Sep;
17(11):1148-1156.
PMID: 34556859
The unfolded protein response (UPR) homeostatically matches endoplasmic reticulum (ER) protein-folding capacity to cellular secretory needs. However, under high or chronic ER stress, the UPR triggers apoptosis. This cell fate...
8.
Brooks J, Tan C, Mueller J, Hibiya K, Hiwa R, Vykunta V, et al.
Cell Rep
. 2021 Sep;
36(9):109645.
PMID: 34469720
B cell clones compete for entry into and dominance within germinal centers (GCs), where the highest-affinity B cell receptors (BCRs) are selected. However, diverse and low-affinity B cells can enter...
9.
Hiwa R, Nielsen H, Mueller J, Mandla R, Zikherman J
JCI Insight
. 2021 Aug;
6(17).
PMID: 34343134
The NR4A family of orphan nuclear receptors (Nr4a1-3) plays redundant roles to establish and maintain Treg identity; deletion of multiple family members in the thymus results in Treg deficiency and...
10.
Tan C, Hiwa R, Mueller J, Vykunta V, Hibiya K, Noviski M, et al.
Nat Immunol
. 2020 Sep;
21(10):1267-1279.
PMID: 32868928
Antigen stimulation (signal 1) triggers B cell proliferation and primes B cells to recruit, engage and respond to T cell help (signal 2). Failure to receive signal 2 within a...