Mark N Adams
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Explore the profile of Mark N Adams including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
841
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Recent Articles
1.
Sadeghirad H, Monkman J, Tan C, Liu N, Yunis J, Donovan M, et al.
J Transl Med
. 2024 Jul;
22(1):677.
PMID: 39049036
Background: Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) generally has a poor prognosis for patients with limited treatment options. While incorporating immune checkpoint inhibitors (ICIs) has now become...
2.
Rose M, Burgess J, Cheong C, Adams M, Shahrouzi P, OByrne K, et al.
Front Oncol
. 2024 May;
14:1222698.
PMID: 38720803
Background: Triple-negative breast cancer (TNBC) is a sub-classification of breast carcinomas, which leads to poor survival outcomes for patients. TNBCs do not possess the hormone receptors that are frequently targeted...
3.
Barbhuiya T, Beard S, Shah E, Mason S, Bolderson E, OByrne K, et al.
ACS Omega
. 2024 Feb;
9(7):8362-8373.
PMID: 38405517
Human single-stranded DNA binding protein 1 (hSSB1) forms a heterotrimeric complex, known as a sensor of single-stranded DNA binding protein 1 (SOSS1), in conjunction with integrator complex subunit 3 (INTS3)...
4.
Shah E, Molloy C, Gough M, Kryza T, Samuel S, Tucker A, et al.
Br J Cancer
. 2024 Jan;
130(7):1196-1205.
PMID: 38287178
Background: 5-Fluorouracil (5-FU) remains a core component of systemic therapy for colorectal cancer (CRC). However, response rates remain low, and development of therapy resistance is a primary issue. Combinatorial strategies...
5.
Schuurs Z, Martyn A, Soltau C, Beard S, Shah E, Adams M, et al.
Biology (Basel)
. 2023 Nov;
12(11).
PMID: 37998004
Human single-stranded DNA binding protein 1 (hSSB1) is critical to preserving genome stability, interacting with single-stranded DNA (ssDNA) through an oligonucleotide/oligosaccharide binding-fold. The depletion of hSSB1 in cell-line models leads...
6.
El-Kamand S, Adams M, Matthews J, Du Plessis M, Crossett B, Connolly A, et al.
Protein Sci
. 2023 Sep;
32(10):e4782.
PMID: 37705456
The repair of double-strand DNA breaks (DSBs) by homologous recombination is crucial in the maintenance of genome integrity. While the key role of the Mre11-Rad50-Nbs1 (MRN) complex in repair is...
7.
Sobanski T, Suraweera A, Burgess J, Richard I, Cheong C, Dave K, et al.
Sci Rep
. 2023 Sep;
13(1):15171.
PMID: 37704669
Glucose metabolism and DNA repair are fundamental cellular processes frequently dysregulated in cancer. In this study, we define a direct role for the glycolytic Aldolase A (ALDOA) protein in DNA...
8.
Bhatia S, Gunter J, Burgess J, Adams M, OByrne K, Thompson E, et al.
Transl Oncol
. 2023 Aug;
37:101760.
PMID: 37611490
Epithelial-mesenchymal plasticity (EMP) is a hallmark of cancer. By enabling cells to shift between different morphological and functional states, EMP promotes invasion, metastasis and therapy resistance. We report that near-diploid...
9.
Sadeghirad H, Liu N, Monkman J, Ma N, Ben Cheikh B, Jhaveri N, et al.
Front Immunol
. 2023 May;
14:1135489.
PMID: 37153589
Mucosal head and neck squamous cell carcinoma (HNSCC) are the seventh most common cancer, with approximately 50% of patients living beyond 5 years. Immune checkpoint inhibitors (ICIs) have shown promising...
10.
Monkman J, Kim H, Mayer A, Mehdi A, Matigian N, Cumberbatch M, et al.
Immunology
. 2023 Apr;
169(4):487-502.
PMID: 37022147
The composition and activation status of the cellular milieu contained within the tumour microenvironment (TME) is becoming increasingly recognized as a driving factor for immunotherapy response. Here, we employed multiplex...