Mark M Rich
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Explore the profile of Mark M Rich including associated specialties, affiliations and a list of published articles.
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87
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2415
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Recent Articles
1.
Foy B, Dupont C, Walker 2nd P, Denman K, Engisch K, Rich M
J Gen Physiol
. 2025 Feb;
157(3).
PMID: 39903205
Patients with periodic paralysis have attacks of weakness precipitated by depolarization of muscle. Each form of periodic paralysis is associated with unique changes in serum K+ during attacks of weakness....
2.
Kerr N, Dashtmian A, Darvishi F, Brennan C, Ayyagari S, Moore P, et al.
Geroscience
. 2025 Jan;
PMID: 39825167
Sarcopenia, the pathological age-related loss of muscle mass and strength, contributes to physical decline, frailty, and diminished healthspan. The impact of sarcopenia is expected to rise as the aging population...
3.
Myers J, Denman K, Dupont C, Foy B, Rich M
J Physiol
. 2024 Oct;
602(22):6171-6188.
PMID: 39392724
Patients with myotonia congenita suffer from slowed muscle relaxation caused by hyperexcitability. The diaphragm is only mildly affected in myotonia congenita; discovery of the mechanism underlying its resistance to myotonia...
4.
Dupont C, Blake B, Voss A, Rich M
Pflugers Arch
. 2024 Aug;
476(11):1693-1702.
PMID: 39150500
Patients with myotonia congenita suffer from slowed relaxation of muscle (myotonia), due to hyperexcitability caused by loss-of-function mutations in the ClC-1 chloride channel. A recent study suggested that block of...
5.
Koesters A, Rich M, Engisch K
bioRxiv
. 2024 Jul;
PMID: 39071374
Following prolonged activity blockade, amplitudes of miniature excitatory postsynaptic currents (mEPSCs) increase, a form of plasticity termed "homeostatic synaptic plasticity." We previously showed that a presynaptic protein, the small GTPase...
6.
Housley S, Gardolinski E, Nardelli P, Reed J, Rich M, Cope T
Exp Physiol
. 2023 Apr;
109(1):35-44.
PMID: 37119460
Our objective was to evaluate an ex vivo muscle-nerve preparation used to study mechanosensory signalling by low threshold mechanosensory receptors (LTMRs). Specifically, we aimed to assess how well the ex...
7.
Kim J, Jha N, Awano T, Caine C, Gollapalli K, Welby E, et al.
Neuron
. 2023 Mar;
111(9):1423-1439.e4.
PMID: 36863345
Reduced survival motor neuron (SMN) protein triggers the motor neuron disease, spinal muscular atrophy (SMA). Restoring SMN prevents disease, but it is not known how neuromuscular function is preserved. We...
8.
Wang X, Dupont C, Grant D, Voss A, Rich M
Exp Neurol
. 2022 Dec;
361:114303.
PMID: 36563835
It has long been accepted that myotonia (muscle stiffness) in patients with muscle channelopathies is due to myotonic discharges (involuntary firing of action potentials). In a previous study, we identified...
9.
Foust K, Wang X, McGovern V, Braun L, Bevan A, Haidet A, et al.
Nat Biotechnol
. 2022 Oct;
40(11):1692.
PMID: 36203015
No abstract available.
10.
Engisch K, Wang X, Rich M
Adv Neurobiol
. 2022 Sep;
28:111-130.
PMID: 36066823
The mammalian neuromuscular junction (NMJ) is an ideal preparation to study synaptic plasticity. Its simplicity- one input, one postsynaptic target- allows experimental manipulations and mechanistic analyses that are impossible at...