Mark L Brantly
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Explore the profile of Mark L Brantly including associated specialties, affiliations and a list of published articles.
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67
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2087
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Recent Articles
1.
Lee J, Mohammad N, Han K, Flagg-Dowie T, Magallon M, Brantly M, et al.
Front Immunol
. 2025 Feb;
16:1543729.
PMID: 40013145
Neutrophilic inflammation and a high level of free α-defensins are main features of chronic airway inflammation in alpha-1 antitrypsin-deficient (AATD) individuals. Despite the antimicrobial activities of α-defensins by direct bacterial...
2.
Lu Y, Mohammad N, Lee J, Aranyos A, Serban K, Brantly M
PLoS One
. 2024 Sep;
19(9):e0310524.
PMID: 39298444
Background: Alpha-1 antitrypsin deficiency (AATD) is an inherited disease, the common variant caused by a Pi*Z mutation in the SERPINA1 gene. Pi*Z AAT increases the risk of pulmonary emphysema and...
3.
Brantly M, Kuhn B, Farah H, Mahadeva R, Cole A, Chang C, et al.
Chronic Obstr Pulm Dis
. 2024 May;
11(3):282-292.
PMID: 38809792
Background: Alpha-1 antitrypsin deficiency (AATD) is characterized by low alpha-1 antitrypsin (AAT) levels, predisposing individuals to lung disease. The standard of care, plasma-derived AAT (pdAAT), is delivered as weekly infusions...
4.
Gogoi D, Yu H, Casey M, Baird R, Yusuf A, Forde L, et al.
Thorax
. 2024 Feb;
79(9):822-833.
PMID: 38418195
Introduction: Altered complement component 3 (C3) activation in patients with alpha-1 antitrypsin (AAT) deficiency (AATD) has been reported. To understand the potential impact on course of inflammation, the aim of...
5.
Riley E, Brunson J, Eydgahi S, Brantly M, Lascano J
ERJ Open Res
. 2023 Sep;
9(5).
PMID: 37727673
Background: Alpha-1 antitrypsin deficiency (AATD) is an under-recognised genetic cause of chronic obstructive lung disease, and many fewer cases than estimated have been identified. Can a reported respiratory and hepatic...
6.
Kuoch H, Krotova K, Graham M, Brantly M, Aslanidi G
Biomedicines
. 2023 Feb;
11(2).
PMID: 36831059
The accurate assessment of AAV-specific pre-existing humoral immunity due to natural viral infection is critical for the efficient use of clinical gene therapy. The method described in the present study...
7.
Kokturk N, Khodayari N, Lascano J, Riley E, Brantly M
Respir Res
. 2023 Feb;
24(1):40.
PMID: 36732772
Background: Alpha-1-antitrypsin deficient (AATD) individuals are prone to develop early age of onset chronic obstructive pulmonary disease (COPD) more severe than non-genetic COPD. Here, we investigated the characteristics of lower...
8.
Wiesemann G, Oshins R, Flagg T, Brantly M
Chronic Obstr Pulm Dis
. 2022 Nov;
10(1):7-21.
PMID: 36367950
The gene encodes the serine protease inhibitor alpha-1 antitrypsin (AAT) and is located on chromosome 14q31-32.3 in a cluster of homologous genes likely formed by exon duplication. AAT has a...
9.
Lu Y, Wang L, Lee J, Mohammad N, Aranyos A, Gould C, et al.
Hepatol Commun
. 2022 Aug;
6(12):3599.
PMID: 36017787
No abstract available.
10.
Lu Y, Wang L, Lee J, Mohammad N, Aranyos A, Gould C, et al.
Hepatol Commun
. 2022 May;
6(9):2354-2367.
PMID: 35621045
Alpha-1 antitrypsin (AAT) deficiency (AATD) is an inherited disease caused by mutations in the serpin family A member 1 (SERPINA1, also known as AAT) gene. The most common variant, PI*Z...