Mark J Bucsek
Overview
Explore the profile of Mark J Bucsek including associated specialties, affiliations and a list of published articles.
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12
Citations
592
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Recent Articles
1.
Qiao G, Chen M, Mohammadpour H, MacDonald C, Bucsek M, Hylander B, et al.
Cancer Immunol Res
. 2021 Mar;
9(6):651-664.
PMID: 33762351
Metabolic dysfunction and exhaustion in tumor-infiltrating T cells have been linked to ineffectual antitumor immunity and the failure of immune checkpoint inhibitor therapy. We report here that chronic stress plays...
2.
Gandhi S, Pandey M, Attwood K, Ji W, Witkiewicz A, Knudsen E, et al.
Clin Cancer Res
. 2020 Oct;
27(1):87-95.
PMID: 33127652
Purpose: Increased β-adrenergic receptor (β-AR) signaling has been shown to promote the creation of an immunosuppressive tumor microenvironment (TME). Preclinical studies have shown that abrogation of this signaling pathway, particularly...
3.
Gandhi S, Pandey M, Ammannagari N, Wang C, Bucsek M, Hamad L, et al.
Immunotherapy
. 2020 Feb;
12(2):141-149.
PMID: 32064978
Patients receiving checkpoint inhibitors (CPI) are frequently on other medications for co-morbidities. We explored the impact of concomitant medication use on outcomes. 210 metastatic cancer patients on CPI were identified...
4.
MacDonald C, Bucsek M, Qiao G, Chen M, Evans L, Greenberg D, et al.
Radiat Res
. 2019 Apr;
191(6):585-589.
PMID: 31021732
While ionizing radiation is a major form of cancer therapy, radioresistance remains a therapeutic obstacle. We have previously shown that the mandated housing temperature for laboratory mice (∼22°C) induces mild,...
5.
Mohammadpour H, Bucsek M, Hylander B, Repasky E
Clin Cancer Res
. 2019 Jan;
25(8):2363-2365.
PMID: 30670491
Depression induces secretion of neuropeptide Y from prostate cancer cells, which, in turn, recruits myeloid-derived suppressor cells (MDSC) to the tumor; tumor cells and MDSCs secrete IL6, which activates STAT3...
6.
Qiao G, Bucsek M, Winder N, Chen M, Giridharan T, Olejniczak S, et al.
Cancer Immunol Immunother
. 2018 Sep;
68(1):11-22.
PMID: 30229289
Primary and secondary lymphoid organs are heavily innervated by the autonomic nervous system. Norepinephrine, the primary neurotransmitter secreted by post-ganglionic sympathetic neurons, binds to and activates β-adrenergic receptors expressed on...
7.
Bucsek M, Giridharan T, MacDonald C, Hylander B, Repasky E
Int J Hyperthermia
. 2018 Mar;
34(2):135-143.
PMID: 29498310
Stress in patients and pre-clinical research animals plays a critical role in disease progression Activation of the sympathetic nervous system (SNS) by stress results in secretion of the catecholamines epinephrine...
8.
Qiao G, Chen M, Bucsek M, Repasky E, Hylander B
Front Immunol
. 2018 Feb;
9:164.
PMID: 29479349
An immune response must be tightly controlled so that it will be commensurate with the level of response needed to protect the organism without damaging normal tissue. The roles of...
9.
Bucsek M, Qiao G, MacDonald C, Giridharan T, Evans L, Niedzwecki B, et al.
Cancer Res
. 2017 Aug;
77(20):5639-5651.
PMID: 28819022
The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We report here that CD8 T-cell frequency and functional...
10.
Ito F, Ku A, Bucsek M, Muhitch J, Vardam-Kaur T, Kim M, et al.
PLoS One
. 2015 Nov;
10(11):e0143370.
PMID: 26599402
Purpose: While surgical resection is a cornerstone of cancer treatment, local and distant recurrences continue to adversely affect outcome in a significant proportion of patients. Evidence that an alternative debulking...