Mark E Bunnage
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Explore the profile of Mark E Bunnage including associated specialties, affiliations and a list of published articles.
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39
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1450
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Recent Articles
1.
Zimmerman B, Dakin L, Fortier A, Nanou E, Blasio A, Mann J, et al.
Nat Commun
. 2025 Jan;
16(1):167.
PMID: 39747090
Chronic kidney disease affects ~10% of people worldwide and there are no disease modifying therapeutics that address the underlying cause of any form of kidney disease. Genome wide association studies...
2.
Egbuna O, Zimmerman B, Manos G, Fortier A, Chirieac M, Dakin L, et al.
N Engl J Med
. 2023 Mar;
388(11):969-979.
PMID: 36920755
Background: Persons with toxic gain-of-function variants in the gene encoding apolipoprotein L1 () are at greater risk for the development of rapidly progressive, proteinuric nephropathy. Despite the known genetic cause,...
3.
Boyd M, Collier P, Clark M, Deng H, Kesavan S, Ronkin S, et al.
J Med Chem
. 2021 Dec;
64(24):17777-17794.
PMID: 34871500
In our efforts to identify novel small molecule inhibitors for the treatment of adrenoleukodystrophy (ALD), we conducted a high-throughput radiometric screen for inhibitors of elongation of very long chain fatty...
4.
Come J, Senter T, Clark M, Court J, Gale-Day Z, Gu W, et al.
J Med Chem
. 2021 Nov;
64(24):17753-17776.
PMID: 34748351
Accumulation of very long chain fatty acids (VLCFAs) due to defects in ATP binding cassette protein D1 (ABCD1) is thought to underlie the pathologies observed in adrenoleukodystrophy (ALD). Pursuing a...
5.
Muller S, Ackloo S, Arrowsmith C, Bauser M, Baryza J, Blagg J, et al.
Elife
. 2018 Apr;
7.
PMID: 29676732
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these...
6.
Jones L, Bunnage M
Nat Rev Drug Discov
. 2017 Jan;
16(4):285-296.
PMID: 28104905
The allure of phenotypic screening, combined with the industry preference for target-based approaches, has prompted the development of innovative chemical biology technologies that facilitate the identification of new therapeutic targets...
7.
Liu S, Dakin L, Xing L, Withka J, Sahasrabudhe P, Li W, et al.
Sci Rep
. 2016 Aug;
6:30859.
PMID: 27527709
Interleukin-17A (IL-17A) is a principal driver of multiple inflammatory and immune disorders. Antibodies that neutralize IL-17A or its receptor (IL-17RA) deliver efficacy in autoimmune diseases, but no small-molecule IL-17A antagonists...
8.
Gerstenberger B, Trzupek J, Tallant C, Fedorov O, Filippakopoulos P, Brennan P, et al.
J Med Chem
. 2016 Apr;
59(10):4800-11.
PMID: 27115555
The acetyl post-translational modification of chromatin at selected histone lysine residues is interpreted by an acetyl-lysine specific interaction with bromodomain reader modules. Here we report the discovery of the potent,...
9.
Fedorov O, Castex J, Tallant C, Owen D, Martin S, Aldeghi M, et al.
Sci Adv
. 2015 Dec;
1(10):e1500723.
PMID: 26702435
Mammalian SWI/SNF [also called Brg/Brahma-associated factors (BAFs)] are evolutionarily conserved chromatin-remodeling complexes regulating gene transcription programs during development and stem cell differentiation. BAF complexes contain an ATP (adenosine 5'-triphosphate)-driven remodeling...
10.
Arrowsmith C, Audia J, Austin C, Baell J, Bennett J, Blagg J, et al.
Nat Chem Biol
. 2015 Oct;
11(11):887.
PMID: 26485080
No abstract available.