Mark Dorward
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Explore the profile of Mark Dorward including associated specialties, affiliations and a list of published articles.
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12
Citations
746
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Recent Articles
1.
Rihn S, Merits A, Bakshi S, Turnbull M, Wickenhagen A, Alexander A, et al.
PLoS Biol
. 2021 Feb;
19(2):e3001091.
PMID: 33630831
The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the underlying cause of Coronavirus Disease 2019 (COVID-19), has led to a worldwide pandemic causing substantial morbidity, mortality, and...
2.
Malik A, Karapetsas A, Nirujogi R, Mathea S, Chatterjee D, Pal P, et al.
Biochem J
. 2021 Jan;
478(3):553-578.
PMID: 33459343
Autosomal dominant mutations in LRRK2 that enhance kinase activity cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases including Rab8A and Rab10 within its effector binding motif. Here, we...
3.
Gordon D, Hiatt J, Bouhaddou M, Rezelj V, Ulferts S, Braberg H, et al.
Science
. 2020 Oct;
370(6521).
PMID: 33060197
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more...
4.
Berndsen K, Lis P, Yeshaw W, Wawro P, Nirujogi R, Wightman M, et al.
Elife
. 2019 Oct;
8.
PMID: 31663853
Mutations that activate LRRK2 protein kinase cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors. An siRNA screen of all human...
5.
Oke M, Carter L, Johnson K, Liu H, McMahon S, Yan X, et al.
J Struct Funct Genomics
. 2010 Apr;
11(2):167-80.
PMID: 20419351
The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These...
6.
Seetharamappa J, Oke M, Liu H, McMahon S, Johnson K, Carter L, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2007 Jun;
63(Pt 5):452-6.
PMID: 17565195
Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase with a molecular weight of 48,168 Da, was overexpressed in methicillin-resistant Staphylococcus aureus compared with a methicillin-sensitive strain. The protein was expressed in Escherichia coli,...
7.
Yard B, Carter L, Johnson K, Overton I, Dorward M, Liu H, et al.
J Mol Biol
. 2007 Jun;
370(5):870-86.
PMID: 17559874
Sphingolipid biosynthesis commences with the condensation of L-serine and palmitoyl-CoA to produce 3-ketodihydrosphingosine (KDS). This reaction is catalysed by the PLP-dependent enzyme serine palmitoyltransferase (SPT; EC 2.3.1.50), which is a...
8.
Seetharamappa J, Oke M, Liu H, McMahon S, Johnson K, Carter L, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2007 Jun;
63(Pt 6):488-91.
PMID: 17554169
Sar2676, a pantothenate synthetase with a molecular weight of 31 419 Da from methicillin-resistant Staphylococcus aureus, has been expressed, purified and crystallized at 293 K. The protein crystallizes in a...
9.
McMahon S, Walsh M, Ching R, Carter L, Dorward M, Johnson K, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2006 Nov;
62(Pt 11):1124-6.
PMID: 17077494
Ranasmurfin, a previously uncharacterized approximately 13 kDa blue protein found in the nests of the frog Polypedates leucomystax, has been purified and crystallized. The crystals are an intense blue colour...
10.
McEwan A, Liu H, Oke M, Carter L, Powers H, Dorward M, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2006 Mar;
62(Pt 3):228-30.
PMID: 16511308
Sso6206, a 10.5 kDa protein from Sulfolobus solfataricus, has been overexpressed, purified and crystallized. The protein crystallizes in space group P6(1/5)22, with unit-cell parameters a = b = 157.8, c...