Geoffrey J Barton
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Explore the profile of Geoffrey J Barton including associated specialties, affiliations and a list of published articles.
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96
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12936
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Recent Articles
1.
Morell T, Procter J, Barton G, Diederichs K, Mayans O, Fleming J
STAR Protoc
. 2025 Feb;
6(1):103603.
PMID: 40019837
Pairwise similarity mapping (PaSiMap), implemented in Jalview, serves as an alternative to principal component analysis (PCA) for analyzing protein sequence relationships without requiring pre-computed multiple sequence alignments. It excels at...
2.
Utges J, Barton G
J Cheminform
. 2024 Nov;
16(1):126.
PMID: 39529176
The accurate identification of protein-ligand binding sites is of critical importance in understanding and modulating protein function. Accordingly, ligand binding site prediction has remained a research focus for over three...
3.
MacGowan S, Madeira F, Britto-Borges T, Barton G
Commun Biol
. 2024 Apr;
7(1):447.
PMID: 38605212
Protein evolution is constrained by structure and function, creating patterns in residue conservation that are routinely exploited to predict structure and other features. Similar constraints should affect variation across individuals,...
4.
Utges J, MacGowan S, Ives C, Barton G
Commun Biol
. 2024 Mar;
7(1):320.
PMID: 38480979
Fragment screening is used to identify binding sites and leads in drug discovery, but it is often unclear which binding sites are functionally important. Here, data from 37 experiments, and...
5.
Parker M, Fica S, Barton G, Simpson G
Elife
. 2023 Oct;
12.
PMID: 37787376
Eukaryotic genes are interrupted by introns that are removed from transcribed RNAs by splicing. Patterns of splicing complexity differ between species, but it is unclear how these differences arise. We...
6.
Kin K, Chen Z, Forbes G, Lawal H, Schilde C, Singh R, et al.
Cell Signal
. 2023 May;
108:110714.
PMID: 37187217
Protein kinases are major regulators of cellular processes, but the roles of most kinases remain unresolved. Dictyostelid social amoebas have been useful in identifying functions for 30% of its kinases...
7.
Parker M, Soanes B, Kusakina J, Larrieu A, Knop K, Joy N, et al.
Elife
. 2022 Nov;
11.
PMID: 36409063
Alternative splicing of messenger RNAs is associated with the evolution of developmentally complex eukaryotes. Splicing is mediated by the spliceosome, and docking of the pre-mRNA 5' splice site into the...
8.
Escudero-Martinez C, Coulter M, Alegria Terrazas R, Foito A, Kapadia R, Pietrangelo L, et al.
Nat Commun
. 2022 Jun;
13(1):3443.
PMID: 35710760
A prerequisite to exploiting soil microbes for sustainable crop production is the identification of the plant genes shaping microbiota composition in the rhizosphere, the interface between roots and soil. Here,...
9.
Bredeson J, Lyons J, Oniyinde I, Okereke N, Kolade O, Nnabue I, et al.
Nat Commun
. 2022 Apr;
13(1):2001.
PMID: 35422045
The nutrient-rich tubers of the greater yam, Dioscorea alata L., provide food and income security for millions of people around the world. Despite its global importance, however, greater yam remains...
10.
MacGowan S, Barton M, Kutuzov M, Dushek O, Anton van der Merwe P, Barton G
PLoS Comput Biol
. 2022 Mar;
18(3):e1009922.
PMID: 35235558
SARS-CoV-2 Spike (Spike) binds to human angiotensin-converting enzyme 2 (ACE2) and the strength of this interaction could influence parameters relating to virulence. To explore whether population variants in ACE2 influence...