Mark D Grier
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Explore the profile of Mark D Grier including associated specialties, affiliations and a list of published articles.
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11
Citations
414
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Recent Articles
1.
Grier M, Yacoub E, Adriany G, Lagore R, Harel N, Zhang R, et al.
Neuroimage
. 2022 Apr;
255:119200.
PMID: 35427769
Diffu0sion-weighted magnetic resonance imaging (dMRI) is a non-invasive imaging technique that provides information about the barriers to the diffusion of water molecules in tissue. In the brain, this information can...
2.
Bullock D, Hayday E, Grier M, Tang W, Pestilli F, Heilbronner S
Cereb Cortex
. 2022 Feb;
32(20):4524-4548.
PMID: 35169827
The functional and computational properties of brain areas are determined, in large part, by their connectivity profiles. Advances in neuroimaging and network neuroscience allow us to characterize the human brain...
3.
Yacoub E, Grier M, Auerbach E, Lagore R, Harel N, Adriany G, et al.
Neuroimage
. 2020 Sep;
223:117349.
PMID: 32898683
Resting state functional connectivity refers to the temporal correlations between spontaneous hemodynamic signals obtained using functional magnetic resonance imaging. This technique has demonstrated that the structure and dynamics of identifiable...
4.
Grier M, Zimmermann J, Heilbronner S
Biol Psychiatry Cogn Neurosci Neuroimaging
. 2020 Jun;
5(9):846-854.
PMID: 32513555
Diffusion-weighted magnetic resonance imaging (dMRI) is a popular tool for noninvasively assessing properties of white matter in the brain. Among other uses, dMRI data can be used to produce estimates...
5.
Grier M, West K, Kelm N, Fu C, Does M, Parker B, et al.
PLoS One
. 2017 Nov;
12(11):e0188417.
PMID: 29161318
Myelin abnormalities are increasingly being recognized as an important component of a number of neurologic developmental disorders. The integration of many signaling pathways and cell types are critical for correct...
6.
Carson R, Kelm N, West K, Does M, Fu C, Weaver G, et al.
Ann Clin Transl Neurol
. 2016 Jan;
2(12):1041-54.
PMID: 26734657
Objective: While abnormalities in myelin in tuberous sclerosis complex (TSC) have been known for some time, recent imaging-based data suggest myelin abnormalities may be independent of the pathognomonic cortical lesions...
7.
Grier M, Carson R, Lagrange A
Behav Brain Res
. 2015 Jun;
291:260-267.
PMID: 26028516
Angelman syndrome (AS) is a neurodevelopmental disorder characterized by a number of neurological problems, including developmental delay, movement disorders, and epilepsy. AS results from the loss of UBE3A (an imprinted...
8.
Grier M, Carson R, Lagrange A
PLoS One
. 2015 Apr;
10(4):e0124649.
PMID: 25894543
Angelman Syndrome (AS) is a devastating neurodevelopmental disorder characterized by developmental delay, speech impairment, movement disorder, sleep disorders and refractory epilepsy. AS is caused by loss of the Ube3a protein...
9.
Rodriguez A, Grier M, Jones C, Herman E, Kane A, Smith R, et al.
Mol Pharmacol
. 2010 Oct;
78(6):1105-23.
PMID: 20923853
Modulators of metabotropic glutamate receptor subtype 5 (mGluR5) may provide novel treatments for multiple central nervous system (CNS) disorders, including anxiety and schizophrenia. Although compounds have been developed to better...
10.
Rodriguez A, Williams R, Zhou Y, Lindsley S, Le U, Grier M, et al.
Bioorg Med Chem Lett
. 2009 May;
19(12):3209-13.
PMID: 19443219
This Letter describes the discovery and SAR of three novel series of mGluR5 non-competitive antagonists/negative allosteric modulators (NAMs) not based on manipulation of an MPEP/MTEP chemotype. This work demonstrates fundamentally...