Mark A Hoon
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Explore the profile of Mark A Hoon including associated specialties, affiliations and a list of published articles.
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42
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4087
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Recent Articles
1.
Bell A, Utting C, Dickie A, Kucharczyk M, Quillet R, Gutierrez-Mecinas M, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(23):e2314213121.
PMID: 38805282
The anterolateral system (ALS) is a major ascending pathway from the spinal cord that projects to multiple brain areas and underlies the perception of pain, itch, and skin temperature. Despite...
2.
Wang H, Flores R, Yarur H, Limoges A, Bravo-Rivera H, Casello S, et al.
Neuron
. 2024 Apr;
112(12):2062-2078.e7.
PMID: 38614102
Prefrontal cortical (PFC) circuits provide top-down control of threat reactivity. This includes ventromedial PFC (vmPFC) circuitry, which plays a role in suppressing fear-related behavioral states. Dynorphin (Dyn) has been implicated...
3.
Nattkemper L, Kim B, Yap Q, Hoon M, Mishra S, Yosipovitch G
J Invest Dermatol
. 2024 Mar;
144(10):2267-2272.
PMID: 38522572
B-type natriuretic peptide (BNP) is an itch-selective neuropeptide that was shown to play a role in both histaminergic and nonhistaminergic itch in mice. It was also shown that elevated serum...
4.
Wang H, Flores R, Yarur H, Limoges A, Bravo-Rivera H, Casello S, et al.
bioRxiv
. 2024 Jan;
PMID: 38283686
Prefrontal cortical (PFC) circuits provide top-down control of threat reactivity. This includes ventromedial PFC (vmPFC) circuitry, which plays a role in suppressing fear-related behavioral states. Dynorphin (Dyn) has been implicated...
5.
Bell A, Utting C, Dickie A, Kucharczyk M, Quillet R, Gutierrez-Mecinas M, et al.
bioRxiv
. 2023 Oct;
PMID: 37786726
The anterolateral system (ALS) is a major ascending pathway from the spinal cord that projects to multiple brain areas and underlies the perception of pain, itch and skin temperature. Despite...
6.
Gu X, Zhang Y, OMalley J, De Preter C, Penzo M, Hoon M
Nat Neurosci
. 2023 Mar;
26(4):594-605.
PMID: 36894654
Supraspinal brain regions modify nociceptive signals in response to various stressors including stimuli that elevate pain thresholds. The medulla oblongata has previously been implicated in this type of pain control,...
7.
Tseng P, Hoon M
Sci Adv
. 2022 Jun;
8(24):eabm7342.
PMID: 35704588
Itch is an unpleasant sensation that often accompanies chronic dermatological conditions. Although many of the itch receptors and the neural pathways underlying this sensation are known, the identity of endogenous...
8.
Tseng P, Hoon M
Sci Transl Med
. 2021 Nov;
13(619):eabe3037.
PMID: 34757808
Chronic itch is a major symptom of many inflammatory skin diseases. This type of pruritus is thought to be facilitated by cytokines that activate cutaneous nerve fibers; however, the molecular...
9.
Tseng P, Hoon M
J Invest Dermatol
. 2021 Oct;
142(1):42-46.
PMID: 34662564
This review focuses on recent advances in understanding the mechanisms involved in itch signaling in the skin and how these new findings fit into the wider picture of the expression...
10.
Tseng P, Hoon M
J Invest Dermatol
. 2021 Sep;
142(3 Pt A):594-602.
PMID: 34480893
Pruritus is a common symptom of dermatological disorders and has a major negative impact on QOL. Previously, it was suggested that human β-defensin peptides elicit itch through the activation of...